SLC25A17

Entrez Summary: N/A
UniProt Summary: Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extent for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3',5'- diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter- exchange mechanism. Inhibited by pyridoxal 5'-phosphate and bathophenanthroline in vitro. {ECO:0000269|PubMed:12445829, ECO:0000269|PubMed:22185573}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

adenine nucleotide transmembrane transporter activity
NAD transmembrane transport
FMN transmembrane transporter activity
NAD transmembrane transporter activity
ADP transmembrane transporter activity
AMP transmembrane transporter activity
coenzyme A transport
AMP transport
adenosine 3,5-bisphosphate transmembrane transport
FAD transmembrane transporter activity
NAD transport
FAD transmembrane transport
coenzyme A transmembrane transporter activity
coenzyme A transmembrane transport
ATP transmembrane transporter activity
ADP transport
nucleotide transmembrane transport
purine-containing compound transmembrane transport
coenzyme transport
fatty acid alpha-oxidation
ATP transport
integral component of peroxisomal membrane
adenine nucleotide transport
purine ribonucleotide transport
purine nucleotide transport
nucleotide transport
organic cation transport
cofactor transport
peroxisomal membrane
fatty acid beta-oxidation
carbohydrate derivative transport
fatty acid transport
fatty acid oxidation
lipid oxidation
fatty acid catabolic process
chaperone binding
peroxisome
monocarboxylic acid catabolic process
organophosphate ester transport
monocarboxylic acid transport