SLC25A23 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC25A23 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC25A23
  * **<color #00a2e8>Official Name</color>**: solute carrier family 25 member 23
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79085|79085]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BV35|Q9BV35]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC25A23&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC25A23|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608746|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane (PubMed:15123600). May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria (PubMed:15123600). Acts as a regulator of mitochondrial calcium uptake via interaction with MCU and MICU1 (PubMed:24430870). {ECO:0000269|PubMed:15123600, ECO:0000269|PubMed:24430870}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mito carr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|urea homeostasis|
|regulation of cellular hyperosmotic salinity response|
|regulation of response to salt stress|
|ATP transmembrane transporter activity|
|regulation of cellular response to osmotic stress|
|calcium import into the mitochondrion|
|positive regulation of mitochondrial calcium ion concentration|
|ATP transport|
|regulation of response to osmotic stress|
|adenine nucleotide transport|
|purine ribonucleotide transport|
|purine nucleotide transport|
|mitochondrial calcium ion transmembrane transport|
|nucleotide transport|
|mitochondrial calcium ion homeostasis|
|regulation of oxidative phosphorylation|
|regulation of cellular respiration|
|calcium ion import|
|carbohydrate derivative transport|
|cellular response to calcium ion|
|cytosolic calcium ion transport|
|mitochondrial transmembrane transport|
|regulation of ATP metabolic process|
|organophosphate ester transport|
|regulation of sequestering of calcium ion|
|drug transport|
|response to calcium ion|
|regulation of generation of precursor metabolites and energy|
|cellular response to metal ion|
|calcium ion transmembrane transport|
|mitochondrial transport|
|cellular response to inorganic substance|
|nucleobase-containing compound transport|
|calcium ion transport|
|divalent metal ion transport|
|divalent inorganic cation transport|
|response to metal ion|
|mitochondrial inner membrane|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|organic anion transport|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|response to inorganic substance|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|anion transport|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cation homeostasis|
|inorganic ion homeostasis|
|calcium ion binding|
|regulation of cellular response to stress|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|cellular homeostasis|
|ion transmembrane transport|
|response to drug|
|chemical homeostasis|
|mitochondrion|
|transmembrane transport|
|ion transport|
|regulation of response to stress|
|regulation of phosphorylation|
|homeostatic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-2|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.74|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17277
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC25A23 Expression in NALM6 Cells: 4.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>