SLC25A23

Entrez Summary: N/A
UniProt Summary: Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane (PubMed:15123600). May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria (PubMed:15123600). Acts as a regulator of mitochondrial calcium uptake via interaction with MCU and MICU1 (PubMed:24430870). {ECO:0000269|PubMed:15123600, ECO:0000269|PubMed:24430870}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

urea homeostasis
regulation of cellular hyperosmotic salinity response
regulation of response to salt stress
ATP transmembrane transporter activity
regulation of cellular response to osmotic stress
calcium import into the mitochondrion
positive regulation of mitochondrial calcium ion concentration
ATP transport
regulation of response to osmotic stress
adenine nucleotide transport
purine ribonucleotide transport
purine nucleotide transport
mitochondrial calcium ion transmembrane transport
nucleotide transport
mitochondrial calcium ion homeostasis
regulation of oxidative phosphorylation
regulation of cellular respiration
calcium ion import
carbohydrate derivative transport
cellular response to calcium ion
cytosolic calcium ion transport
mitochondrial transmembrane transport
regulation of ATP metabolic process
organophosphate ester transport
regulation of sequestering of calcium ion
drug transport
response to calcium ion
regulation of generation of precursor metabolites and energy
cellular response to metal ion
calcium ion transmembrane transport
mitochondrial transport
cellular response to inorganic substance
nucleobase-containing compound transport
calcium ion transport
divalent metal ion transport
divalent inorganic cation transport
response to metal ion
mitochondrial inner membrane
cellular calcium ion homeostasis
calcium ion homeostasis