SLC25A36 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC25A36 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC25A36
  * **<color #00a2e8>Official Name</color>**: solute carrier family 25 member 36
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55186|55186]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96CQ1|Q96CQ1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC25A36&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC25A36|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616149|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially cytosine and uracil (deoxy)nucleoside mono-, di-, and triphosphates by uniport and antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10- phenanthroline, tannic acid, and mercurials (mercury dichloride, Mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration. {ECO:0000269|PubMed:25320081}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mito carr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pyrimidine nucleotide transmembrane transporter activity|
|pyrimidine nucleotide import into mitochondrion|
|pyrimidine nucleotide transport|
|nucleotide transmembrane transport|
|pyrimidine-containing compound transmembrane transport|
|mitochondrial genome maintenance|
|nucleotide transport|
|regulation of mitochondrial membrane potential|
|mitochondrial transmembrane transport|
|organophosphate ester transport|
|mitochondrial transport|
|nucleobase-containing compound transport|
|mitochondrial inner membrane|
|regulation of membrane potential|
|mitochondrion organization|
|mitochondrion|
|transmembrane transport|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.14|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.83|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.77|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.72|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|1.78|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|1.95|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|2.03|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|2.39|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|3.97|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|4.16|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrs2|MRS2]]|0.543|
|[[:human genes:p:prim1|PRIM1]]|0.502|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.484|
|[[:human genes:p:polr2j3|POLR2J3]]|0.469|
|[[:human genes:s:slc25a33|SLC25A33]]|0.446|
|[[:human genes:m:mgme1|MGME1]]|0.442|
|[[:human genes:s:syt9|SYT9]]|0.431|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 19026
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC25A36 Expression in NALM6 Cells: 6.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>