SLC25A36

Entrez Summary: N/A
UniProt Summary: Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially cytosine and uracil (deoxy)nucleoside mono-, di-, and triphosphates by uniport and antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10- phenanthroline, tannic acid, and mercurials (mercury dichloride, Mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration. {ECO:0000269|PubMed:25320081}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Clomiphene 4.4μM R02 exp68	-2.14
Tubacin 1.6μM R07 exp416	-1.83
Pimelic-diphenylamide-106 5μM R00 exp28	-1.77
3-Bromopyruvate 7μM R04 exp175	1.72
Calcipotriol 5μM R08 exp464	1.78
UM0011500 10μM R05 exp246	1.95
Alpha-Amanitin 0.5μM R00 exp5	2.03
Chloramphenicol 2μM R00 exp12	2.39
Doxycycline 10μM R00 exp18	3.97
Hypoxia 5%O2 R04 exp191	4.16

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

pyrimidine nucleotide transmembrane transporter activity
pyrimidine nucleotide import into mitochondrion
pyrimidine nucleotide transport
nucleotide transmembrane transport
pyrimidine-containing compound transmembrane transport
mitochondrial genome maintenance
nucleotide transport
regulation of mitochondrial membrane potential
mitochondrial transmembrane transport
organophosphate ester transport
mitochondrial transport
nucleobase-containing compound transport
mitochondrial inner membrane
regulation of membrane potential
mitochondrion organization
mitochondrion
transmembrane transport
nitrogen compound transport