SLC25A51 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC25A51 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC25A51
  * **<color #00a2e8>Official Name</color>**: solute carrier family 25 member 51
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=92014|92014]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H1U9|Q9H1U9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC25A51&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC25A51|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619153|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mito carr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial inner membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.7|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.7|
|[[:results:exp518|RK-33 8μM R08 exp518]]|1.72|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|1.73|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|1.73|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.76|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.77|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.78|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.81|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|1.85|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.88|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.89|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.9|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|1.93|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.94|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.94|
|[[:results:exp359|FK-506 30μM R07 exp359]]|2.08|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.14|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.21|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.22|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|2.29|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|2.46|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|2.47|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|2.56|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.59|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.79|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.81|
|[[:results:exp59|UMK57 1μM R01 exp59]]|3.1|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|3.12|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|3.35|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|3.39|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|3.92|
|[[:results:exp360|Genistein 15μM R07 exp360]]|4.06|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|4.12|
|[[:results:exp116|AICAR 240μM R03 exp116]]|4.19|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|4.24|
|[[:results:exp211|AICAR 240μM R05 exp211]]|4.28|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|4.34|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|4.48|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|4.79|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|4.98|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|5.04|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|6.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nubpl|NUBPL]]|0.51|
|[[:human genes:a:acad9|ACAD9]]|0.497|
|[[:human genes:p:prim1|PRIM1]]|0.489|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.474|
|[[:human genes:n:ndufs2|NDUFS2]]|0.47|
|[[:human genes:n:ndufa1|NDUFA1]]|0.468|
|[[:human genes:n:ndufb9|NDUFB9]]|0.467|
|[[:human genes:n:ndufb11|NDUFB11]]|0.466|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.463|
|[[:human genes:p:polg2|POLG2]]|0.461|
|[[:human genes:p:polrmt|POLRMT]]|0.46|
|[[:human genes:n:ndufb4|NDUFB4]]|0.452|
|[[:human genes:p:pet117|PET117]]|0.444|
|[[:human genes:n:ndufa8|NDUFA8]]|0.44|
|[[:human genes:w:wars2|WARS2]]|0.44|
|[[:human genes:n:ndufa2|NDUFA2]]|0.435|
|[[:human genes:n:ndufv2|NDUFV2]]|0.433|
|[[:human genes:m:mrps27|MRPS27]]|0.431|
|[[:human genes:n:ndufc2|NDUFC2]]|0.429|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.429|
|[[:human genes:l:lars2|LARS2]]|0.429|
|[[:human genes:n:ndufv1|NDUFV1]]|0.429|
|[[:human genes:n:ndufb7|NDUFB7]]|0.428|
|[[:human genes:n:nars2|NARS2]]|0.428|
|[[:human genes:f:ftsj2|FTSJ2]]|0.424|
|[[:human genes:m:mtif2|MTIF2]]|0.424|
|[[:human genes:g:grsf1|GRSF1]]|0.423|
|[[:human genes:n:ndufa13|NDUFA13]]|0.422|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.418|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.416|
|[[:human genes:s:slc25a3|SLC25A3]]|0.413|
|[[:human genes:p:pars2|PARS2]]|0.411|
|[[:human genes:m:mettl17|METTL17]]|0.411|
|[[:human genes:q:qrsl1|QRSL1]]|0.408|
|[[:human genes:m:mthfd1l|MTHFD1L]]|0.407|
|[[:human genes:n:ndufa9|NDUFA9]]|0.405|
|[[:human genes:a:aars2|AARS2]]|0.404|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 423
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC25A51 Expression in NALM6 Cells: 4.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>