SLC25A5 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC25A5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC25A5
  * **<color #00a2e8>Official Name</color>**: solute carrier family 25 member 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=292|292]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05141|P05141]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC25A5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC25A5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300150|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Jun 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. {ECO:0000269|PubMed:20797633}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mito carr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|adenine transmembrane transporter activity|
|adenine transport|
|ATP:ADP antiporter activity|
|MMXD complex|
|ADP transport|
|purine nucleobase transport|
|negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|nucleobase transport|
|ATP transport|
|adenine nucleotide transport|
|purine ribonucleotide transport|
|purine nucleotide transport|
|nucleotide transport|
|mitochondrial nucleoid|
|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|negative regulation of mitochondrion organization|
|carbohydrate derivative transport|
|regulation of mitochondrial membrane permeability|
|regulation of membrane permeability|
|cellular response to leukemia inhibitory factor|
|response to leukemia inhibitory factor|
|organophosphate ester transport|
|mitochondrial membrane organization|
|drug transport|
|regulation of insulin secretion|
|regulation of mitochondrion organization|
|regulation of peptide hormone secretion|
|mitochondrial transport|
|negative regulation of apoptotic signaling pathway|
|membrane raft|
|nucleobase-containing compound transport|
|regulation of hormone secretion|
|chromosome segregation|
|ubiquitin protein ligase binding|
|negative regulation of organelle organization|
|mitochondrial inner membrane|
|regulation of apoptotic signaling pathway|
|mitochondrion organization|
|organic anion transport|
|regulation of protein secretion|
|negative regulation of transport|
|regulation of peptide secretion|
|regulation of hormone levels|
|anion transport|
|viral process|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|symbiotic process|
|regulation of secretion|
|interspecies interaction between organisms|
|membrane organization|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|response to drug|
|regulation of protein localization|
|response to cytokine|
|mitochondrion|
|negative regulation of signal transduction|
|transmembrane transport|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|RNA binding|
|integral component of plasma membrane|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of cell death|
|nitrogen compound transport|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-3.01|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2.55|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-2.42|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|-1.79|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|1.78|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.01|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|3.49|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.437|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 19040
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC25A5 Expression in NALM6 Cells: 8.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>