SLC25A5

Entrez Summary: This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Jun 2013].
UniProt Summary: Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. {ECO:0000269|PubMed:20797633}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
2-Deoxy-D-glucose 800μM R05 exp214	-3.01
Oligomycin-A 2μM R00 exp25	-2.55
Hypoxia 5%O2 R04 exp191	-2.42
Lead acetate 990μM R08 exp496	-1.79
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	1.78
Artemisinin 50μM R08 exp450	2.01
Nifuroxazide 5μM R03 exp102	3.49

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

adenine transmembrane transporter activity
adenine transport
ATP:ADP antiporter activity
MMXD complex
ADP transport
purine nucleobase transport
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
nucleobase transport
ATP transport
adenine nucleotide transport
purine ribonucleotide transport
purine nucleotide transport
nucleotide transport
mitochondrial nucleoid
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
negative regulation of mitochondrion organization
carbohydrate derivative transport
regulation of mitochondrial membrane permeability
regulation of membrane permeability
cellular response to leukemia inhibitory factor
response to leukemia inhibitory factor
organophosphate ester transport
mitochondrial membrane organization
drug transport
regulation of insulin secretion
regulation of mitochondrion organization
regulation of peptide hormone secretion
mitochondrial transport
negative regulation of apoptotic signaling pathway
membrane raft
nucleobase-containing compound transport
regulation of hormone secretion
chromosome segregation
ubiquitin protein ligase binding
negative regulation of organelle organization
mitochondrial inner membrane
regulation of apoptotic signaling pathway
mitochondrion organization
organic anion transport
regulation of protein secretion