SLC26A1

Entrez Summary: This gene is a member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures, but have markedly different tissue expression patterns. This gene is primarily expressed in the liver, pancreas, and brain. Three splice variants that encode different isoforms have been identified. [provided by RefSeq, Jul 2008].
UniProt Summary: Mediates sulfate transport with high affinity (PubMed:12713736). Mediates oxalate transport (PubMed:12713736). Mediates bicarbonate transport (By similarity). Does not accept succinate as cosubstrate (By similarity). {ECO:0000250|UniProtKB:P45380, ECO:0000250|UniProtKB:P58735, ECO:0000269|PubMed:12713736}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

STAS
Sulfate transp

purine ribonucleoside bisphosphate biosynthetic process
3-phosphoadenosine 5-phosphosulfate biosynthetic process
oxalate transmembrane transporter activity
secondary active sulfate transmembrane transporter activity
oxalate transport
bicarbonate transmembrane transporter activity
sulfate transmembrane transporter activity
chloride transmembrane transporter activity
sulfate transmembrane transport
sulfate transport
anion:anion antiporter activity
3-phosphoadenosine 5-phosphosulfate metabolic process
purine ribonucleoside bisphosphate metabolic process
bicarbonate transport
sulfur compound transport
purine nucleoside bisphosphate biosynthetic process
nucleoside bisphosphate biosynthetic process
ribonucleoside bisphosphate biosynthetic process
dicarboxylic acid transport
chloride transmembrane transport
chloride transport
inorganic anion transmembrane transport
ribonucleoside bisphosphate metabolic process
nucleoside bisphosphate metabolic process
purine nucleoside bisphosphate metabolic process
purine ribonucleotide biosynthetic process
purine nucleotide biosynthetic process
inorganic anion transport
ribonucleotide biosynthetic process
ribose phosphate biosynthetic process
purine-containing compound biosynthetic process
sulfur compound biosynthetic process
basolateral plasma membrane
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
anion transmembrane transport
carboxylic acid transport
organic acid transport
purine ribonucleotide metabolic process
ribonucleotide metabolic process