SLC2A5

Entrez Summary: The protein encoded by this gene is a fructose transporter responsible for fructose uptake by the small intestine. The encoded protein also is necessary for the increase in blood pressure due to high dietary fructose consumption. [provided by RefSeq, Jun 2016].
UniProt Summary: Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:8333543). Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed:1695905). Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake (By similarity). {ECO:0000250|UniProtKB:Q9WV38, ECO:0000269|PubMed:1695905, ECO:0000269|PubMed:8333543}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Sugar tr
MFS 1

carbohydrate import across plasma membrane
fructose import
hexose import across plasma membrane
fructose import across plasma membrane
cellular response to fructose stimulus
fructose binding
fructose transmembrane transporter activity
intestinal hexose absorption
fructose transmembrane transport
response to fructose
glucose transmembrane transporter activity
intestinal absorption
glucose transmembrane transport
hexose transmembrane transport
monosaccharide transmembrane transport
carbohydrate transmembrane transport
regulation of systemic arterial blood pressure mediated by a chemical signal
cellular response to hexose stimulus
cellular response to monosaccharide stimulus
digestive system process
carbohydrate transport
cellular response to carbohydrate stimulus
specific granule membrane
regulation of systemic arterial blood pressure
import across plasma membrane
sarcolemma
digestion
response to hexose
response to monosaccharide
response to carbohydrate
regulation of blood pressure
apical plasma membrane
blood circulation
circulatory system process
carbohydrate metabolic process
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation