SLC2A8 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC2A8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC2A8
  * **<color #00a2e8>Official Name</color>**: solute carrier family 2 member 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29988|29988]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NY64|Q9NY64]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC2A8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC2A8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605245|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Insulin-regulated facilitative glucose transporter. Binds cytochalasin B in a glucose-inhibitable manner. Seems to be a dual-specific sugar transporter as it is inhibitable by fructose (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MFS 1|
|Sugar tr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|fructose transmembrane transporter activity|
|carbohydrate:proton symporter activity|
|dehydroascorbic acid transmembrane transporter activity|
|fructose transmembrane transport|
|dehydroascorbic acid transport|
|glucose binding|
|glucose transmembrane transporter activity|
|male meiosis I|
|glucose transmembrane transport|
|hexose transmembrane transport|
|monosaccharide transmembrane transport|
|carbohydrate transmembrane transport|
|vitamin transport|
|male meiotic nuclear division|
|clathrin-coated vesicle membrane|
|carbohydrate transport|
|insulin receptor signaling pathway|
|meiosis I|
|meiosis I cell cycle process|
|synaptic vesicle|
|proton transmembrane transport|
|meiotic nuclear division|
|cellular response to insulin stimulus|
|meiotic cell cycle process|
|meiotic cell cycle|
|response to insulin|
|cellular response to peptide hormone stimulus|
|nuclear division|
|lysosomal membrane|
|organelle fission|
|cellular response to peptide|
|response to hypoxia|
|cellular process involved in reproduction in multicellular organism|
|response to decreased oxygen levels|
|response to oxygen levels|
|response to peptide hormone|
|monovalent inorganic cation transport|
|organic anion transport|
|response to peptide|
|carbohydrate metabolic process|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|inorganic cation transmembrane transport|
|male gamete generation|
|anion transport|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cation transmembrane transport|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|gamete generation|
|enzyme linked receptor protein signaling pathway|
|multicellular organismal reproductive process|
|cation transport|
|sexual reproduction|
|multicellular organism reproduction|
|membrane organization|
|response to hormone|
|ion transmembrane transport|
|multi-organism reproductive process|
|cell cycle process|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|transmembrane transport|
|cell cycle|
|ion transport|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|response to oxygen-containing compound|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.78|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7101
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC2A8 Expression in NALM6 Cells: 2.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>