SLC2A8

Entrez Summary: N/A
UniProt Summary: Insulin-regulated facilitative glucose transporter. Binds cytochalasin B in a glucose-inhibitable manner. Seems to be a dual-specific sugar transporter as it is inhibitable by fructose (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
MLN-4924 2μM R00 exp22	-1.78
TGF-beta1 44ng/ml R08 exp528	1.7

MFS 1
Sugar tr

fructose transmembrane transporter activity
carbohydrate:proton symporter activity
dehydroascorbic acid transmembrane transporter activity
fructose transmembrane transport
dehydroascorbic acid transport
glucose binding
glucose transmembrane transporter activity
male meiosis I
glucose transmembrane transport
hexose transmembrane transport
monosaccharide transmembrane transport
carbohydrate transmembrane transport
vitamin transport
male meiotic nuclear division
clathrin-coated vesicle membrane
carbohydrate transport
insulin receptor signaling pathway
meiosis I
meiosis I cell cycle process
synaptic vesicle
proton transmembrane transport
meiotic nuclear division
cellular response to insulin stimulus
meiotic cell cycle process
meiotic cell cycle
response to insulin
cellular response to peptide hormone stimulus
nuclear division
lysosomal membrane
organelle fission
cellular response to peptide
response to hypoxia
cellular process involved in reproduction in multicellular organism
response to decreased oxygen levels
response to oxygen levels
response to peptide hormone
monovalent inorganic cation transport
organic anion transport
response to peptide
carbohydrate metabolic process