SLC30A2

Entrez Summary: The protein encoded by this gene is a zinc transporter that acts as a homodimer. The encoded protein plays a role in secreting zinc into breast milk. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Nifurtimox 1μM R03 exp141	-1.76
GSK-J5 1.5μM R08 exp484	1.78

positive regulation of sequestering of zinc ion
regulation of sequestering of zinc ion
zinc ion transmembrane transporter activity
zinc ion transmembrane transport
zinc ion transport
response to zinc ion
transition metal ion transport
late endosome
divalent metal ion transport
lysosomal membrane
divalent inorganic cation transport
response to metal ion
response to inorganic substance
inorganic cation transmembrane transport
cation transmembrane transport
metal ion transport
inorganic ion transmembrane transport
intracellular membrane-bounded organelle
ion homeostasis
cation transport
ion transmembrane transport
chemical homeostasis
transmembrane transport
ion transport
homeostatic process