SLC35B3

Gene Information

Official Symbol: SLC35B3
Official Name: solute carrier family 35 member B3
Aliases and Previous Symbols: N/A
Entrez ID: 51000
UniProt: Q9H1N7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Mediates the transport of adenosine 3'-phospho 5'- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon. {ECO:0000269|PubMed:16492677}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16279
Expression level (log2 read counts): 3.93

Expression Distribution

3-phosphoadenosine 5-phosphosulfate transmembrane transporter activity
3-phosphoadenosine 5-phosphosulfate transport
3-phospho-5-adenylyl sulfate transmembrane transport
purine ribonucleoside bisphosphate biosynthetic process
3-phosphoadenosine 5-phosphosulfate biosynthetic process
nucleotide transmembrane transport
purine-containing compound transmembrane transport
adenine nucleotide transport
purine ribonucleotide transport
purine nucleotide transport
nucleotide transport
3-phosphoadenosine 5-phosphosulfate metabolic process
purine ribonucleoside bisphosphate metabolic process
sulfur compound transport
nucleoside bisphosphate biosynthetic process
purine nucleoside bisphosphate biosynthetic process
ribonucleoside bisphosphate biosynthetic process
transmembrane transporter activity
integral component of Golgi membrane
carbohydrate derivative transport
integral component of endoplasmic reticulum membrane
organophosphate ester transport
ribonucleoside bisphosphate metabolic process
purine nucleoside bisphosphate metabolic process
nucleoside bisphosphate metabolic process
purine ribonucleotide biosynthetic process
purine nucleotide biosynthetic process
ribonucleotide biosynthetic process
ribose phosphate biosynthetic process
purine-containing compound biosynthetic process
sulfur compound biosynthetic process
nucleobase-containing compound transport
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
anion transmembrane transport
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
sulfur compound metabolic process