SLC36A4

Entrez Summary: N/A
UniProt Summary: Functions as a sodium-independent electroneutral transporter for tryptophan, proline and alanine. Inhibited by sarcosine. {ECO:0000269|PubMed:21097500}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

proline import across plasma membrane
L-proline transmembrane transport
L-proline import across plasma membrane
L-tryptophan transmembrane transporter activity
L-tryptophan transmembrane transport
tryptophan transport
L-alanine transmembrane transporter activity
L-proline transmembrane transporter activity
proline transmembrane transport
L-alanine transport
proline transport
alanine transport
aromatic amino acid transport
amino acid import across plasma membrane
amino acid import
neutral amino acid transport
amino acid transmembrane transporter activity
symporter activity
L-alpha-amino acid transmembrane transport
L-amino acid transport
drug transmembrane transport
amino acid transmembrane transport
import across plasma membrane
amino acid transport
carboxylic acid transmembrane transport
organic acid transmembrane transport
drug transport
anion transmembrane transport
carboxylic acid transport
organic acid transport
organic anion transport
anion transport
cation transmembrane transport
import into cell
cation transport
ion transmembrane transport
response to drug
transmembrane transport
ion transport
nitrogen compound transport