SLC39A5

Entrez Summary: The protein encoded by this gene belongs to the ZIP family of zinc transporters that transport zinc into cells from outside, and play a crucial role in controlling intracellular zinc levels. Zinc is an essential cofactor for many enzymes and proteins involved in gene transcription, growth, development and differentiation. Mutations in this gene have been associated with autosomal dominant high myopia (MYP24). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014].
UniProt Summary: May play a role in polarized cells by carrying out serosal-to-mucosal zinc transport. Plays a role in eye development. Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera (PubMed:24891338). Seems to play a central role in controlling organismal zinc status (By similarity). {ECO:0000250|UniProtKB:Q9D856, ECO:0000269|PubMed:24891338}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

response to zinc ion starvation
cellular response to zinc ion starvation
G1 to G0 transition involved in cell differentiation
zinc ion import across plasma membrane
G1 to G0 transition
zinc ion transmembrane transporter activity
positive regulation of mRNA splicing, via spliceosome
zinc ion transmembrane transport
zinc ion transport
positive regulation of mRNA processing
cellular zinc ion homeostasis
positive regulation of RNA splicing
zinc ion homeostasis
neural precursor cell proliferation
inorganic ion import across plasma membrane
inorganic cation import across plasma membrane
positive regulation of mRNA metabolic process
BMP signaling pathway
import across plasma membrane
regulation of mRNA splicing, via spliceosome
cellular response to BMP stimulus
response to BMP
cellular transition metal ion homeostasis
transition metal ion transport
transition metal ion homeostasis
regulation of RNA splicing
regulation of mRNA processing
cellular response to starvation
response to starvation
basolateral plasma membrane
transmembrane receptor protein serine/threonine kinase signaling pathway
cellular response to nutrient levels
cellular response to extracellular stimulus
divalent metal ion transport
divalent inorganic cation transport
regulation of mRNA metabolic process
cellular response to external stimulus
eye development
visual system development
sensory system development