SLC39A8

• Official Symbol: SLC39A8
• Official Name: solute carrier family 39 member 8
• Aliases and Previous Symbols: N/A
• Entrez ID: 64116
• UniProt: Q9C0K1
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: This gene encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary transporter of the toxic cation cadmium, which is found in cigarette smoke. Multiple transcript variants encoding different isoforms have been found for this gene. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Oct 2008].
• UniProt Summary: Acts as a manganese and zinc influx transporter (PubMed:12504855, PubMed:26637978). Plays a role in manganese reabsorption in the proximal tubule of the kidney and in manganese uptake into the brain (PubMed:26637978). {ECO:0000269|PubMed:12504855, ECO:0000305|PubMed:26637978}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 17323
• Expression level (log2 read counts): 6.76

Expression Distribution

×

SLC39A8 Expression in NALM6 Cells: 6.76