SLC4A3

Entrez Summary: The protein encoded by this gene is a plasma membrane anion exchange protein. The encoded protein has been found in brain, heart, kidney, small intestine, and lung. [provided by RefSeq, May 2016].
UniProt Summary: Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl(-)/HCO3(-) exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl(-).

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Bisphenol F 50μM R08 exp457	1.7
Rifampicin 30μM R08 exp430	1.73

Band 3 cyto
HCO3 cotransp

inorganic anion exchanger activity
anion:anion antiporter activity
bicarbonate transport
regulation of intracellular pH
regulation of cellular pH
regulation of pH
cellular monovalent inorganic cation homeostasis
monovalent inorganic cation homeostasis
inorganic anion transport
anion transmembrane transport
organic anion transport
anion transport
cellular cation homeostasis
cellular ion homeostasis
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis
ion homeostasis
cellular homeostasis
ion transmembrane transport
chemical homeostasis
transmembrane transport
ion transport
integral component of plasma membrane
homeostatic process
membrane