SLC51B

Gene Information

Official Symbol: SLC51B
Official Name: solute carrier family 51 subunit beta
Aliases and Previous Symbols: N/A
Entrez ID: 123264
UniProt: Q86UW2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities. {ECO:0000269|PubMed:16317684}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6415
Expression level (log2 read counts): -2.28

Expression Distribution

bile acid secretion
positive regulation of protein glycosylation
bile acid transmembrane transporter activity
positive regulation of protein exit from endoplasmic reticulum
regulation of protein glycosylation
positive regulation of glycoprotein biosynthetic process
positive regulation of glycoprotein metabolic process
regulation of protein exit from endoplasmic reticulum
bile acid and bile salt transport
positive regulation of protein targeting to membrane
regulation of protein targeting to membrane
regulation of glycoprotein biosynthetic process
regulation of glycoprotein metabolic process
acid secretion
regulation of protein targeting
positive regulation of protein localization to membrane
monocarboxylic acid transport
organic hydroxy compound transport
positive regulation of intracellular protein transport
regulation of protein localization to membrane
basolateral plasma membrane
positive regulation of intracellular transport
regulation of intracellular protein transport
regulation of protein stability
carboxylic acid transport
organic acid transport
lipid transport
lipid localization
positive regulation of cellular protein localization
regulation of intracellular transport
positive regulation of protein transport
organic anion transport
positive regulation of establishment of protein localization
protein heterodimerization activity
regulation of cellular protein localization
anion transport
protein-containing complex
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization