SLC5A5 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC5A5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC5A5
  * **<color #00a2e8>Official Name</color>**: solute carrier family 5 member 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6528|6528]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92911|Q92911]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC5A5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC5A5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601843|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1.[provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates iodide uptake in the thyroid gland.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SSF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sodium:iodide symporter activity|
|iodide transmembrane transporter activity|
|iodide transport|
|thyroid hormone generation|
|thyroid hormone metabolic process|
|cellular response to gonadotropin stimulus|
|response to gonadotropin|
|cellular response to cAMP|
|extracellular vesicle|
|phenol-containing compound metabolic process|
|response to cAMP|
|response to organophosphorus|
|response to purine-containing compound|
|sodium ion transport|
|inorganic anion transport|
|cellular modified amino acid metabolic process|
|hormone metabolic process|
|monovalent inorganic cation transport|
|organic hydroxy compound metabolic process|
|regulation of hormone levels|
|cellular response to organic cyclic compound|
|anion transport|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|metal ion transport|
|cellular response to nitrogen compound|
|cation transport|
|response to hormone|
|response to organic cyclic compound|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|cellular response to endogenous stimulus|
|transmembrane transport|
|ion transport|
|response to endogenous stimulus|
|response to oxygen-containing compound|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|1.7|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2.11|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|2.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:ddtl|DDTL]]|0.48|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.466|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.461|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.441|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.44|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.439|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.438|
|[[:human genes:c:cope|COPE]]|0.43|
|[[:human genes:o:orc6|ORC6]]|0.427|
|[[:human genes:w:wdr87|WDR87]]|0.427|
|[[:human genes:h:hivep3|HIVEP3]]|0.425|
|[[:human genes:s:slc6a17|SLC6A17]]|0.422|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.42|
|[[:human genes:o:orc1|ORC1]]|0.418|
|[[:human genes:s:sec13|SEC13]]|0.418|
|[[:human genes:s:slc4a1|SLC4A1]]|0.416|
|[[:human genes:p:psmd3|PSMD3]]|0.407|
|[[:human genes:l:loc643669|LOC643669]]|0.406|
|[[:human genes:k:kif3c|KIF3C]]|0.404|
|[[:human genes:c:cgb2|CGB2]]|0.404|
|[[:human genes:g:golga6a|GOLGA6A]]|0.402|
|[[:human genes:a:ankle1|ANKLE1]]|0.401|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.401|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2464
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC5A5 Expression in NALM6 Cells: 1.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>