SLC6A15

Entrez Summary: N/A
UniProt Summary: Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent. {ECO:0000269|PubMed:16226721}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

proline:sodium symporter activity
leucine transport
branched-chain amino acid transport
neurotransmitter transmembrane transporter activity
proline transport
neurotransmitter:sodium symporter activity
neutral amino acid transport
amino acid transmembrane transporter activity
amino acid transmembrane transport
amino acid transport
carboxylic acid transmembrane transport
organic acid transmembrane transport
sodium ion transport
neurotransmitter transport
anion transmembrane transport
carboxylic acid transport
organic acid transport
monovalent inorganic cation transport
organic anion transport
anion transport
metal ion transport
cation transport
ion transmembrane transport
transmembrane transport
ion transport
integral component of plasma membrane
nitrogen compound transport