SLC6A19

Entrez Summary: This gene encodes a system B(0) transmembrane protein that actively transports most neutral amino acids across the apical membrane of epithelial cells. Mutations in this gene result in Hartnup disorder. [provided by RefSeq, Jul 2008].
UniProt Summary: Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells. This uptake is sodium-dependent and chloride- independent. {ECO:0000269|PubMed:15286788}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

neutral amino acid transmembrane transporter activity
neurotransmitter:sodium symporter activity
neutral amino acid transport
amino acid transmembrane transporter activity
brush border membrane
amino acid transmembrane transport
amino acid transport
carboxylic acid transmembrane transport
organic acid transmembrane transport
neurotransmitter transport
response to nutrient
anion transmembrane transport
organic acid transport
carboxylic acid transport
apical plasma membrane
organic anion transport
response to nutrient levels
response to extracellular stimulus
anion transport
ion transmembrane transport
transmembrane transport
ion transport
integral component of plasma membrane
nitrogen compound transport