SLC6A2

Entrez Summary: This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010].
UniProt Summary: Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals. {ECO:0000269|PubMed:2008212}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

norepinephrine:sodium symporter activity
norepinephrine uptake
norepinephrine transport
dopamine uptake involved in synaptic transmission
dopamine:sodium symporter activity
catecholamine uptake involved in synaptic transmission
monoamine transmembrane transporter activity
dopamine uptake
catecholamine uptake
dopamine transport
neurotransmitter:sodium symporter activity
catecholamine transport
neurotransmitter reuptake
synaptic transmission, dopaminergic
monoamine transport
neuronal cell body membrane
neurotransmitter uptake
response to pain
neuron cellular homeostasis
beta-tubulin binding
alpha-tubulin binding
ammonium transport
multicellular organismal response to stress
presynaptic membrane
organic hydroxy compound transport
drug transport
neurotransmitter transport
membrane raft
actin binding
neuron projection
anatomical structure homeostasis
regulation of neurotransmitter levels
anterograde trans-synaptic signaling
chemical synaptic transmission
trans-synaptic signaling
synaptic signaling
cell surface
import into cell
cation transport
cellular homeostasis