SLC6A5

Entrez Summary: This gene encodes a sodium- and chloride-dependent glycine neurotransmitter transporter. This integral membrane glycoprotein is responsible for the clearance of extracellular glycine during glycine-mediated neurotransmission. This protein is found in glycinergic axons and maintains a high presynaptic pool of neurotransmitter at glycinergic synapses. Mutations in this gene cause hyperekplexia; a heterogenous neurological disorder characterized by exaggerated startle responses and neonatal apnea. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016].
UniProt Summary: Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses. {ECO:0000269|PubMed:10381548, ECO:0000269|PubMed:10606742, ECO:0000269|PubMed:9845349}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

glycine import across plasma membrane
glycine:sodium symporter activity
synaptic transmission, glycinergic
glycinergic synapse
glycine transport
amino acid import across plasma membrane
amino acid import
neurotransmitter uptake
neutral amino acid transport
L-alpha-amino acid transmembrane transport
integral component of presynaptic membrane
L-amino acid transport
drug transmembrane transport
amino acid transmembrane transport
import across plasma membrane
amino acid transport
carboxylic acid transmembrane transport
organic acid transmembrane transport
drug transport
neurotransmitter transport
anion transmembrane transport
carboxylic acid transport
organic acid transport
regulation of neurotransmitter levels
anterograde trans-synaptic signaling
chemical synaptic transmission
trans-synaptic signaling
organic anion transport
synaptic signaling
anion transport
cation transmembrane transport
import into cell
cation transport
ion transmembrane transport
response to drug
cell-cell signaling
transmembrane transport
ion transport
nitrogen compound transport