SLC6A9

Entrez Summary: The amino acid glycine acts as an inhibitory neurotransmitter in the central nervous system. The protein encoded by this gene is one of two transporters that stop glycine signaling by removing it from the synaptic cleft. [provided by RefSeq, Jun 2016].
UniProt Summary: Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Etoposide 10μM R00 exp20	-2.45
AICAR 240μM R03 exp116	-2.08

glycine secretion, neurotransmission
glycine secretion
regulation of synaptic transmission, glycinergic
glycine:sodium symporter activity
glycine transmembrane transporter activity
synaptic transmission, glycinergic
glycine transport
parallel fiber to Purkinje cell synapse
neurotransmitter uptake
integral component of synaptic vesicle membrane
hippocampal mossy fiber to CA3 synapse
neutral amino acid transport
integral component of postsynaptic membrane
integral component of presynaptic membrane
L-amino acid transport
amino acid transmembrane transport
acid secretion
neurotransmitter secretion
signal release from synapse
amino acid transport
carboxylic acid transmembrane transport
organic acid transmembrane transport
drug transport
signal release
neurotransmitter transport
postsynaptic density
anion transmembrane transport
organic acid transport
carboxylic acid transport
regulation of neurotransmitter levels
chemical synaptic transmission
anterograde trans-synaptic signaling
trans-synaptic signaling
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
organic anion transport
synaptic signaling
anion transport
import into cell
cation transport