SLC7A3

Entrez Summary: This gene encodes a member of the solute carrier family 7. The encoded protein is a sodium-independent cationic amino acid transporter. Alternate splicing results in multiple transcripts that encoded the same protein.[provided by RefSeq, May 2010].
UniProt Summary: Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. {ECO:0000269|PubMed:11591158}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

L-arginine import across plasma membrane
L-lysine transmembrane transporter activity
arginine transmembrane transporter activity
L-lysine transport
L-arginine transmembrane transport
L-ornithine transmembrane transporter activity
L-lysine transmembrane transport
ornithine transport
L-ornithine transmembrane transport
L-arginine transport
arginine transmembrane transport
arginine transport
basic amino acid transmembrane transport
basic amino acid transport
amino acid import across plasma membrane
amino acid import
amino acid transmembrane transporter activity
L-alpha-amino acid transmembrane transport
L-amino acid transport
drug transmembrane transport
amino acid transmembrane transport
import across plasma membrane
amino acid transport
organic acid transmembrane transport
carboxylic acid transmembrane transport
drug transport
anion transmembrane transport
carboxylic acid transport
organic acid transport
organic anion transport
anion transport
cation transmembrane transport
import into cell
cation transport
ion transmembrane transport
response to drug
transmembrane transport
ion transport
nitrogen compound transport