SLC7A9
Gene Information
- Official Symbol: SLC7A9
- Official Name: solute carrier family 7 member 9
- Aliases and Previous Symbols: N/A
- Entrez ID: 11136
- UniProt: P82251
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a protein that belongs to a family of light subunits of amino acid transporters. This protein plays a role in the high-affinity and sodium-independent transport of cystine and neutral and dibasic amino acids, and appears to function in the reabsorption of cystine in the kidney tubule. Mutations in this gene cause non-type I cystinuria, a disease that leads to cystine stones in the urinary system due to impaired transport of cystine and dibasic amino acids. Alternate transcript variants, which encode the same protein, have been found for this gene. [provided by RefSeq, Jul 2011].
- UniProt Summary: Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high- affinity reabsorption of cystine in the kidney tubule. {ECO:0000269|PubMed:10471498, ECO:0000269|PubMed:10588648, ECO:0000269|PubMed:16609684}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 6502
- Expression level (log2 read counts): 0.3
SLC7A9 Expression in NALM6 Cells: 0.3
