SLC9B2 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC9B2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC9B2
  * **<color #00a2e8>Official Name</color>**: solute carrier family 9 member B2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=133308|133308]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86UD5|Q86UD5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC9B2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC9B2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611789|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Na(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane (PubMed:18000046, PubMed:28154142, PubMed:22948142, PubMed:18508966). Contributes to the regulation of intracellular pH, sodium homeostasis, and cell volume. Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta- cells (By similarity). Involved in sperm motility and fertility (By similarity). It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not (By similarity). {ECO:0000250|UniProtKB:Q5BKR2, ECO:0000269|PubMed:18000046, ECO:0000269|PubMed:18508966, ECO:0000269|PubMed:22948142, ECO:0000269|PubMed:28154142}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Na H Exchanger|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|monovalent cation:proton antiporter activity|
|lithium:proton antiporter activity|
|positive regulation of osteoclast development|
|positive regulation of bone development|
|regulation of osteoclast development|
|sodium:proton antiporter activity|
|sperm principal piece|
|regulation of bone development|
|clathrin-dependent endocytosis|
|positive regulation of osteoclast differentiation|
|positive regulation of myeloid leukocyte differentiation|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|regulation of osteoclast differentiation|
|synaptic vesicle membrane|
|sperm motility|
|flagellated sperm motility|
|sodium ion transmembrane transport|
|positive regulation of myeloid cell differentiation|
|cilium or flagellum-dependent cell motility|
|cilium-dependent cell motility|
|mitochondrial membrane|
|regulation of myeloid leukocyte differentiation|
|proton transmembrane transport|
|positive regulation of leukocyte differentiation|
|sodium ion transport|
|regulation of insulin secretion|
|positive regulation of hemopoiesis|
|basolateral plasma membrane|
|regulation of peptide hormone secretion|
|endosome membrane|
|regulation of myeloid cell differentiation|
|receptor-mediated endocytosis|
|regulation of hormone secretion|
|regulation of leukocyte differentiation|
|apical plasma membrane|
|mitochondrial inner membrane|
|monovalent inorganic cation transport|
|regulation of hemopoiesis|
|regulation of protein secretion|
|regulation of peptide secretion|
|regulation of hormone levels|
|positive regulation of cell development|
|cell junction|
|endocytosis|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|import into cell|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|cation transport|
|regulation of cellular localization|
|regulation of cell development|
|ion transmembrane transport|
|positive regulation of cell differentiation|
|regulation of protein localization|
|identical protein binding|
|localization of cell|
|cell motility|
|positive regulation of immune system process|
|transmembrane transport|
|locomotion|
|positive regulation of developmental process|
|ion transport|
|reproductive process|
|reproduction|
|movement of cell or subcellular component|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10367
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC9B2 Expression in NALM6 Cells: 4.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>