SLC9B2

Entrez Summary: N/A
UniProt Summary: Na(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane (PubMed:18000046, PubMed:28154142, PubMed:22948142, PubMed:18508966). Contributes to the regulation of intracellular pH, sodium homeostasis, and cell volume. Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta- cells (By similarity). Involved in sperm motility and fertility (By similarity). It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not (By similarity). {ECO:0000250|UniProtKB:Q5BKR2, ECO:0000269|PubMed:18000046, ECO:0000269|PubMed:18508966, ECO:0000269|PubMed:22948142, ECO:0000269|PubMed:28154142}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

monovalent cation:proton antiporter activity
lithium:proton antiporter activity
positive regulation of osteoclast development
positive regulation of bone development
regulation of osteoclast development
sodium:proton antiporter activity
sperm principal piece
regulation of bone development
clathrin-dependent endocytosis
positive regulation of osteoclast differentiation
positive regulation of myeloid leukocyte differentiation
regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of osteoclast differentiation
synaptic vesicle membrane
sperm motility
flagellated sperm motility
sodium ion transmembrane transport
positive regulation of myeloid cell differentiation
cilium or flagellum-dependent cell motility
cilium-dependent cell motility
mitochondrial membrane
regulation of myeloid leukocyte differentiation
proton transmembrane transport
positive regulation of leukocyte differentiation
sodium ion transport
regulation of insulin secretion
positive regulation of hemopoiesis
basolateral plasma membrane
regulation of peptide hormone secretion
endosome membrane
regulation of myeloid cell differentiation
receptor-mediated endocytosis
regulation of hormone secretion
regulation of leukocyte differentiation
apical plasma membrane
mitochondrial inner membrane
monovalent inorganic cation transport
regulation of hemopoiesis
regulation of protein secretion
regulation of peptide secretion