SLIT3
Gene Information
- Official Symbol: SLIT3
- Official Name: slit guidance ligand 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 6586
- UniProt: O75094
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012].
- UniProt Summary: May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.
Pfam Domains GO Terms
Pfam Domains
| LRRNT |
| Laminin G 2 |
| EGF |
| Laminin G 1 |
| LRR 4 |
GO Terms
| chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration |
| apoptotic process involved in luteolysis |
| embryonic olfactory bulb interneuron precursor migration |
| Roundabout signaling pathway |
| response to cortisol |
| negative regulation of chemokine-mediated signaling pathway |
| luteolysis |
| tangential migration from the subventricular zone to the olfactory bulb |
| Roundabout binding |
| neuron projection extension involved in neuron projection guidance |
| axon extension involved in axon guidance |
| olfactory bulb interneuron development |
| regulation of chemokine-mediated signaling pathway |
| substrate-independent telencephalic tangential migration |
| substrate-independent telencephalic tangential interneuron migration |
| olfactory bulb interneuron differentiation |
| atrioventricular valve morphogenesis |
| atrioventricular valve development |
| apoptotic process involved in development |
| aortic valve morphogenesis |
| forebrain neuron development |
| olfactory bulb development |
| aortic valve development |
| olfactory lobe development |
| axon extension |
| semi-lunar valve development |
| ventricular septum morphogenesis |
| ovulation cycle process |
| negative chemotaxis |
| forebrain neuron differentiation |
| heart valve morphogenesis |
| telencephalon cell migration |
| neuron projection extension |
| heart valve development |
| negative regulation of cytokine-mediated signaling pathway |
| forebrain cell migration |
| negative regulation of response to cytokine stimulus |
| forebrain generation of neurons |
| ovulation cycle |
| ventricular septum development |
| cardiac septum morphogenesis |
| central nervous system neuron development |
| female gonad development |
| developmental cell growth |
| cell growth |
| development of primary female sexual characteristics |
| female sex differentiation |
| cardiac septum development |
| developmental growth involved in morphogenesis |
| cardiac chamber morphogenesis |
| cardiac ventricle development |
| response to glucocorticoid |
| response to corticosteroid |
| regulation of cytokine-mediated signaling pathway |
| heparin binding |
| cardiac chamber development |
| regulation of response to cytokine stimulus |
| central nervous system neuron differentiation |
| negative regulation of cell growth |
| response to ketone |
| gonad development |
| development of primary sexual characteristics |
| response to alcohol |
| negative regulation of growth |
| heart morphogenesis |
| telencephalon development |
| axon guidance |
| neuron projection guidance |
| sex differentiation |
| rhythmic process |
| response to steroid hormone |
| cellular process involved in reproduction in multicellular organism |
| axonogenesis |
| forebrain development |
| developmental growth |
| growth |
| axon development |
| regulation of cell growth |
| reproductive structure development |
| reproductive system development |
| cell morphogenesis involved in neuron differentiation |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| cell part morphogenesis |
| heart development |
| chemotaxis |
| taxis |
| cell morphogenesis involved in differentiation |
| cellular response to hormone stimulus |
| neuron projection development |
| developmental process involved in reproduction |
| regulation of growth |
| negative regulation of cell population proliferation |
| calcium ion binding |
| cell morphogenesis |
| brain development |
| head development |
| neuron development |
| cellular component morphogenesis |
| multicellular organismal reproductive process |
| multicellular organism reproduction |
| response to lipid |
| circulatory system development |
| response to hormone |
| response to organic cyclic compound |
| apoptotic process |
| animal organ morphogenesis |
| cell migration |
| central nervous system development |
| neuron differentiation |
| response to drug |
| programmed cell death |
| cell motility |
| localization of cell |
| cell death |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| cellular response to endogenous stimulus |
| mitochondrion |
| negative regulation of signal transduction |
| locomotion |
| negative regulation of cell communication |
| negative regulation of signaling |
| reproductive process |
| reproduction |
| response to endogenous stimulus |
| generation of neurons |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| extracellular space |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| cell development |
| negative regulation of gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| CCT251545 0.2μM R06 exp271 | -2.05 |
| MLN-4924 0.2μM R00 exp21 | 1.74 |
| Actinomycin-D 0.001μM R00 exp3 | 2.02 |
| ABT-702 5μM R07 exp318 | 2.3 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8832
- Expression level (log2 read counts): 1.43
Expression Distribution
SLIT3 Expression in NALM6 Cells: 1.43
