SLN [The Human Chemical-Genetic Interaction Map Project]

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======= SLN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLN
  * **<color #00a2e8>Official Name</color>**: sarcolipin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6588|6588]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00631|O00631]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602203|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. Required for muscle-based, non-shivering thermogenesis (By similarity). {ECO:0000250|UniProtKB:Q9CQD6, ECO:0000269|PubMed:11781085, ECO:0000269|PubMed:9575189}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sarcolipin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of calcium ion binding|
|regulation of calcium ion binding|
|negative regulation of calcium ion import|
|regulation of ATPase-coupled calcium transmembrane transporter activity|
|regulation of relaxation of muscle|
|sarcoplasmic reticulum calcium ion transport|
|positive regulation of protein depolymerization|
|sarcoplasmic reticulum membrane|
|enzyme inhibitor activity|
|negative regulation of calcium ion transmembrane transporter activity|
|positive regulation of protein complex disassembly|
|regulation of calcium ion import|
|negative regulation of calcium ion transmembrane transport|
|sarcoplasmic reticulum|
|negative regulation of calcium ion transport|
|negative regulation of protein complex disassembly|
|negative regulation of ion transmembrane transporter activity|
|negative regulation of transporter activity|
|ATPase binding|
|negative regulation of cation transmembrane transport|
|regulation of protein depolymerization|
|regulation of calcium ion transmembrane transporter activity|
|negative regulation of ion transmembrane transport|
|positive regulation of cold-induced thermogenesis|
|regulation of protein complex disassembly|
|negative regulation of transmembrane transport|
|regulation of cold-induced thermogenesis|
|negative regulation of ion transport|
|regulation of calcium ion transmembrane transport|
|negative regulation of binding|
|regulation of muscle system process|
|regulation of calcium ion transport|
|calcium ion transport|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|regulation of transporter activity|
|divalent metal ion transport|
|divalent inorganic cation transport|
|regulation of cation transmembrane transport|
|regulation of binding|
|regulation of metal ion transport|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|regulation of transmembrane transport|
|regulation of system process|
|metal ion transport|
|regulation of ion transport|
|negative regulation of cellular component organization|
|negative regulation of catalytic activity|
|cation transport|
|negative regulation of molecular function|
|positive regulation of cellular component organization|
|ion transport|
|positive regulation of multicellular organismal process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-1.86|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-1.86|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.7|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|1.72|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|1.73|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.74|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.76|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.92|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.94|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|2.33|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12147
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLN Expression in NALM6 Cells: -5.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>