SLN

Gene Information

Official Symbol: SLN
Official Name: sarcolipin
Aliases and Previous Symbols: N/A
Entrez ID: 6588
UniProt: O00631
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. Required for muscle-based, non-shivering thermogenesis (By similarity). {ECO:0000250|UniProtKB:Q9CQD6, ECO:0000269|PubMed:11781085, ECO:0000269|PubMed:9575189}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Pterostilbene 16μM R02 exp78	-1.86
Pyronaridine 1μM R06 exp295	-1.86
GSK461364A 0.1μM R03 exp126	1.7
SGC2096 2.6μM R03 exp153	1.72
Resveratrol 16μM R03 exp147	1.73
MLN-4924 0.2μM R00 exp21	1.74
AICAR 240μM R03 exp116	1.76
All-trans-Retinoic-Acid 40μM R07 exp334	1.92
Bleomycin 5μM R08 exp459	1.94
Q15 1 to 2μM on day4 R04 exp164	2.33

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12147
Expression level (log2 read counts): -5.01

Expression Distribution

negative regulation of calcium ion binding
regulation of calcium ion binding
negative regulation of calcium ion import
regulation of ATPase-coupled calcium transmembrane transporter activity
regulation of relaxation of muscle
sarcoplasmic reticulum calcium ion transport
positive regulation of protein depolymerization
sarcoplasmic reticulum membrane
enzyme inhibitor activity
negative regulation of calcium ion transmembrane transporter activity
positive regulation of protein complex disassembly
regulation of calcium ion import
negative regulation of calcium ion transmembrane transport
sarcoplasmic reticulum
negative regulation of calcium ion transport
negative regulation of protein complex disassembly
negative regulation of ion transmembrane transporter activity
negative regulation of transporter activity
ATPase binding
negative regulation of cation transmembrane transport
regulation of protein depolymerization
regulation of calcium ion transmembrane transporter activity
negative regulation of ion transmembrane transport
positive regulation of cold-induced thermogenesis
regulation of protein complex disassembly
negative regulation of transmembrane transport
regulation of cold-induced thermogenesis
negative regulation of ion transport
regulation of calcium ion transmembrane transport
negative regulation of binding
regulation of muscle system process
regulation of calcium ion transport
calcium ion transport
regulation of ion transmembrane transporter activity
regulation of transmembrane transporter activity
regulation of transporter activity
divalent metal ion transport
divalent inorganic cation transport
regulation of cation transmembrane transport
regulation of binding