SLU7 [The Human Chemical-Genetic Interaction Map Project]

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======= SLU7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLU7
  * **<color #00a2e8>Official Name</color>**: SLU7 homolog, splicing factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10569|10569]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95391|O95391]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLU7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLU7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605974|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'- splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. {ECO:0000269|PubMed:10197984, ECO:0000269|PubMed:10647016, ECO:0000269|PubMed:12764196, ECO:0000269|PubMed:15728250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Slu7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|second spliceosomal transesterification activity|
|mRNA 3-splice site recognition|
|pre-mRNA 3-splice site binding|
|small nuclear ribonucleoprotein complex|
|alternative mRNA splicing, via spliceosome|
|mRNA splice site selection|
|spliceosomal complex assembly|
|cellular response to heat|
|mRNA 3-end processing|
|catalytic step 2 spliceosome|
|spliceosomal complex|
|mRNA export from nucleus|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|response to heat|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|RNA 3-end processing|
|protein export from nucleus|
|mRNA transport|
|nuclear export|
|response to temperature stimulus|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|RNA localization|
|ribonucleoprotein complex assembly|
|nucleobase-containing compound transport|
|ribonucleoprotein complex subunit organization|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|nuclear speck|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|intracellular membrane-bounded organelle|
|mRNA metabolic process|
|zinc ion binding|
|cellular protein-containing complex assembly|
|RNA processing|
|intracellular protein transport|
|response to abiotic stimulus|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|RNA metabolic process|
|cellular response to stress|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp218|A-395 10μM R05 exp218]]|-1.74|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|1.72|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.74|
|[[:results:exp100|NFN1 1μM R03 exp100]]|1.8|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|1.81|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.94|
|[[:results:exp483|FTY720 3μM R08 exp483]]|2.05|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|2.13|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|2.15|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.428|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 691/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|27/28|
|bone|24/26|
|breast|30/33|
|central nervous system|52/56|
|cervix|3/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|0/1|
|gastric|16/16|
|kidney|15/21|
|liver|19/20|
|lung|67/75|
|lymphocyte|16/16|
|ovary|24/26|
|pancreas|22/24|
|peripheral nervous system|16/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|27/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2360
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLU7 Expression in NALM6 Cells: 5.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>