SLU7

Entrez Summary: N/A
UniProt Summary: Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'- splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. {ECO:0000269|PubMed:10197984, ECO:0000269|PubMed:10647016, ECO:0000269|PubMed:12764196, ECO:0000269|PubMed:15728250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 691/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	27/28
bone	24/26
breast	30/33
central nervous system	52/56
cervix	3/4
colorectal	17/17
esophagus	13/13
fibroblast	0/1
gastric	16/16
kidney	15/21
liver	19/20
lung	67/75
lymphocyte	16/16
ovary	24/26
pancreas	22/24
peripheral nervous system	16/16
plasma cell	14/15
prostate	1/1
skin	22/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	27/29
uterus	4/5

Expression Distribution

second spliceosomal transesterification activity
mRNA 3-splice site recognition
pre-mRNA 3-splice site binding
small nuclear ribonucleoprotein complex
alternative mRNA splicing, via spliceosome
mRNA splice site selection
spliceosomal complex assembly
cellular response to heat
mRNA 3-end processing
catalytic step 2 spliceosome
spliceosomal complex
mRNA export from nucleus
mRNA-containing ribonucleoprotein complex export from nucleus
response to heat
ribonucleoprotein complex export from nucleus
ribonucleoprotein complex localization
RNA export from nucleus
RNA 3-end processing
protein export from nucleus
mRNA transport
nuclear export
response to temperature stimulus
nucleic acid transport
RNA transport
establishment of RNA localization
RNA localization
ribonucleoprotein complex assembly
nucleobase-containing compound transport
ribonucleoprotein complex subunit organization
protein-containing complex localization
nucleocytoplasmic transport
nuclear transport
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
RNA splicing
nuclear speck
ribonucleoprotein complex biogenesis
mRNA processing
intracellular membrane-bounded organelle