SMARCA5

Official Symbol: SMARCA5
Official Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
Aliases and Previous Symbols: N/A
Entrez ID: 8467
UniProt: O60264
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. {ECO:0000269|PubMed:10880450, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:12198550, ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:12972596, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 6/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	2/28
bone	0/25
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
UMK57 0.6μM R03 exp107	1.72
Lead acetate 2000μM R08 exp498 no dilution day6	1.85
Deguelin 0.15μM R05 exp209	2.02

RSF complex
chromatin silencing complex
NURF complex
chromatin silencing at rDNA
nuclear replication fork
nucleosome positioning
nucleosome binding
condensed chromosome
CENP-A containing chromatin organization
CENP-A containing nucleosome assembly
chromatin remodeling at centromere
helicase activity
centromere complex assembly
DNA replication-independent nucleosome assembly
DNA replication-independent nucleosome organization
DNA-dependent ATPase activity
histone exchange
chromatin silencing
chromatin organization involved in negative regulation of transcription
positive regulation of gene expression, epigenetic
chromatin organization involved in regulation of transcription
ATP-dependent chromatin remodeling
negative regulation of gene expression, epigenetic
response to leukemia inhibitory factor
cellular response to leukemia inhibitory factor
nucleosome assembly
histone binding
fibrillar center
chromatin assembly
gene silencing
chromatin assembly or disassembly
nucleosome organization
chromatin remodeling
DNA packaging
protein-DNA complex assembly
DNA-templated transcription, initiation
ATPase activity
regulation of gene expression, epigenetic
protein-DNA complex subunit organization
DNA conformation change