SMC2 [The Human Chemical-Genetic Interaction Map Project]

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======= SMC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SMC2
  * **<color #00a2e8>Official Name</color>**: structural maintenance of chromosomes 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10592|10592]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95347|O95347]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SMC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SMC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605576|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SMC N|
|SMC hinge|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|meiotic chromosome condensation|
|condensin complex|
|mitotic chromosome condensation|
|kinetochore organization|
|condensed chromosome|
|nuclear chromosome|
|chromosome condensation|
|chromosome organization involved in meiotic cell cycle|
|meiotic chromosome segregation|
|single-stranded DNA binding|
|mitotic sister chromatid segregation|
|sister chromatid segregation|
|mitotic nuclear division|
|meiotic nuclear division|
|meiotic cell cycle process|
|DNA packaging|
|nuclear chromosome segregation|
|meiotic cell cycle|
|chromosome segregation|
|nuclear division|
|DNA conformation change|
|organelle fission|
|protein heterodimerization activity|
|cell division|
|mitotic cell cycle process|
|mitotic cell cycle|
|nucleolus|
|cell cycle process|
|chromosome organization|
|cell cycle|
|reproductive process|
|reproduction|
|ATP binding|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-2.94|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-2.69|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-2.51|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-2.25|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-2.11|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-2.03|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.9|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-1.88|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.81|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.74|
|[[:results:exp169|BH1 1μM R04 exp169]]|1.72|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|1.72|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|1.74|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.75|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|1.75|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|1.75|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|1.77|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|1.83|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|1.88|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|1.88|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|1.96|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|2.01|
|[[:results:exp136|MS094 2μM R03 exp136]]|2.04|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.05|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|2.11|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.25|
|[[:results:exp115|A-366 10μM R03 exp115]]|2.31|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|2.38|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|2.46|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rpl35|RPL35]]|0.42|
|[[:human genes:d:ddtl|DDTL]]|0.415|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 723/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/25|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|14/14|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1047
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SMC2 Expression in NALM6 Cells: 7.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>