SMC2

Entrez Summary: N/A
UniProt Summary: Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 723/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	25/25
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	15/15
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	14/14
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	7/7
thyroid	2/2
upper aerodigestive	22/22
urinary tract	28/29
uterus	4/5

Expression Distribution

Gene	Correlation
RPL35	0.42
DDTL	0.415

SMC N
SMC hinge

meiotic chromosome condensation
condensin complex
mitotic chromosome condensation
kinetochore organization
condensed chromosome
nuclear chromosome
chromosome condensation
chromosome organization involved in meiotic cell cycle
meiotic chromosome segregation
single-stranded DNA binding
mitotic sister chromatid segregation
sister chromatid segregation
mitotic nuclear division
meiotic nuclear division
meiotic cell cycle process
DNA packaging
nuclear chromosome segregation
meiotic cell cycle
chromosome segregation
nuclear division
DNA conformation change
organelle fission
protein heterodimerization activity
cell division
mitotic cell cycle process
mitotic cell cycle
nucleolus
cell cycle process
chromosome organization
cell cycle
reproductive process
reproduction
ATP binding
protein-containing complex subunit organization