SMOC2

Gene Information

Official Symbol: SMOC2
Official Name: SPARC related modular calcium binding 2
Aliases and Previous Symbols: N/A
Entrez ID: 64094
UniProt: Q9H3U7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40), which are highly expressed during embryogenesis and wound healing. The gene product is a matricellular protein which promotes matrix assembly and can stimulate endothelial cell proliferation and migration, as well as angiogenic activity. Associated with pulmonary function, this secretory gene product contains a Kazal domain, two thymoglobulin type-1 domains, and two EF-hand calcium-binding domains. The encoded protein may serve as a target for controlling angiogenesis in tumor growth and myocardial ischemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14926
Expression level (log2 read counts): 7.26

Expression Distribution

SPARC Ca bdg
Kazal 2
Thyroglobulin 1

positive regulation of vascular wound healing
positive regulation of vascular endothelial growth factor signaling pathway
regulation of vascular wound healing
positive regulation of fibroblast growth factor receptor signaling pathway
interstitial matrix
positive regulation of endothelial cell chemotaxis
regulation of vascular endothelial growth factor signaling pathway
regulation of cellular response to vascular endothelial growth factor stimulus
regulation of endothelial cell chemotaxis
regulation of fibroblast growth factor receptor signaling pathway
cell periphery
positive regulation of wound healing
positive regulation of response to wounding
positive regulation of DNA biosynthetic process
basement membrane
positive regulation of endothelial cell migration
regulation of DNA biosynthetic process
positive regulation of cell-substrate adhesion
positive regulation of chemotaxis
regulation of wound healing
positive regulation of epithelial cell migration
positive regulation of mitotic cell cycle
regulation of endothelial cell migration
positive regulation of angiogenesis
regulation of response to wounding
heparin binding
positive regulation of vasculature development
positive regulation of DNA metabolic process
regulation of cell-substrate adhesion
regulation of chemotaxis
regulation of epithelial cell migration
regulation of cellular response to growth factor stimulus
regulation of angiogenesis
regulation of vasculature development
extracellular matrix organization
regulation of DNA metabolic process
positive regulation of cell cycle
extracellular structure organization
positive regulation of cell adhesion
positive regulation of cell migration