SMPD2

Entrez Summary: N/A
UniProt Summary: Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2- lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso- sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

sphingomyelin phosphodiesterase activity
sphingomyelin catabolic process
positive regulation of sphingolipid biosynthetic process
positive regulation of ceramide biosynthetic process
sphingomyelin metabolic process
regulation of sphingolipid biosynthetic process
regulation of membrane lipid metabolic process
regulation of ceramide biosynthetic process
sphingolipid catabolic process
phospholipid catabolic process
membrane lipid catabolic process
ceramide biosynthetic process
glycosphingolipid metabolic process
caveola
positive regulation of lipid biosynthetic process
ceramide metabolic process
sphingolipid biosynthetic process
glycolipid metabolic process
liposaccharide metabolic process
organophosphate catabolic process
membrane lipid biosynthetic process
positive regulation of lipid metabolic process
positive regulation of cellular amide metabolic process
sphingolipid metabolic process
regulation of lipid biosynthetic process
ammonium ion metabolic process
cellular lipid catabolic process
membrane lipid metabolic process
response to mechanical stimulus
lipid catabolic process
phospholipid metabolic process
regulation of lipid metabolic process
regulation of cellular amide metabolic process
amide biosynthetic process
lipid biosynthetic process
cellular amide metabolic process
organophosphate metabolic process
cellular lipid metabolic process
regulation of cellular component biogenesis
carbohydrate derivative metabolic process