SMPDL3B

Entrez Summary: N/A
UniProt Summary: Lipid-modulating phosphodiesterase (PubMed:26095358). Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling (By similarity). {ECO:0000250|UniProtKB:P58242, ECO:0000269|PubMed:26095358}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

hydrolase activity, acting on glycosyl bonds
sphingomyelin phosphodiesterase activity
sphingomyelin catabolic process
phosphoric diester hydrolase activity
sphingomyelin metabolic process
sphingolipid catabolic process
phospholipid catabolic process
membrane lipid catabolic process
negative regulation of toll-like receptor signaling pathway
regulation of toll-like receptor signaling pathway
anchored component of membrane
organophosphate catabolic process
negative regulation of inflammatory response
sphingolipid metabolic process
ammonium ion metabolic process
cellular lipid catabolic process
membrane lipid metabolic process
negative regulation of defense response
lipid catabolic process
regulation of inflammatory response
negative regulation of response to external stimulus
phospholipid metabolic process
negative regulation of immune system process
regulation of innate immune response
inflammatory response
regulation of response to biotic stimulus
regulation of defense response
innate immune response
regulation of multi-organism process
cellular amide metabolic process
zinc ion binding
organophosphate metabolic process
defense response to other organism
cellular lipid metabolic process
organonitrogen compound catabolic process
regulation of response to external stimulus
regulation of immune response
lipid metabolic process
negative regulation of signal transduction
response to other organism