SMS [The Human Chemical-Genetic Interaction Map Project]

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======= SMS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SMS
  * **<color #00a2e8>Official Name</color>**: spermine synthase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6611|6611]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P52788|P52788]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SMS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SMS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300105|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein belonging to the spermidine/spermin synthase family and catalyzes the production of spermine from spermidine. Pseudogenes of this gene are located on chromosomes 1, 5, 6 and X. Mutations in this gene cause an X-linked intellectual disability called Snyder-Robinson Syndrome (SRS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM).

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Spermine synth|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|spermine synthase activity|
|spermine biosynthetic process|
|spermine metabolic process|
|polyamine biosynthetic process|
|methionine metabolic process|
|polyamine metabolic process|
|cellular biogenic amine biosynthetic process|
|amine biosynthetic process|
|sulfur amino acid metabolic process|
|aspartate family amino acid metabolic process|
|cellular biogenic amine metabolic process|
|cellular amine metabolic process|
|amine metabolic process|
|ammonium ion metabolic process|
|alpha-amino acid metabolic process|
|cellular amino acid metabolic process|
|sulfur compound metabolic process|
|drug metabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp134|MS023 2μM R03 exp134]]|-2.25|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.17|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.98|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-1.79|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.77|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.74|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|1.71|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|2.06|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.09|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.26|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rqcd1|RQCD1]]|0.416|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5325
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SMS Expression in NALM6 Cells: 6.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>