SMS

Entrez Summary: This gene encodes a protein belonging to the spermidine/spermin synthase family and catalyzes the production of spermine from spermidine. Pseudogenes of this gene are located on chromosomes 1, 5, 6 and X. Mutations in this gene cause an X-linked intellectual disability called Snyder-Robinson Syndrome (SRS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017].
UniProt Summary: Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM).

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MS023 2μM R03 exp134	-2.25
Vincristine 0.0005μM R04 exp190	-2.17
Colchicine 0.009μM R05 exp215	-1.98
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-1.79
Mdivi-1 15μM R05 exp217	-1.77
GSK626616 14μM R08 exp485	-1.74
GSK2606414 1μM R05 exp236	1.71
Calcium Ionophore 0.4μM R07 exp342	2.06
Vemurafenib 6.6μM R08 exp434	2.09
Vemurafenib 6.6μM R02 exp89	2.26
Azithromycin 100μM R08 exp452	2.83

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

spermine synthase activity
spermine biosynthetic process
spermine metabolic process
polyamine biosynthetic process
methionine metabolic process
polyamine metabolic process
cellular biogenic amine biosynthetic process
amine biosynthetic process
sulfur amino acid metabolic process
aspartate family amino acid metabolic process
cellular biogenic amine metabolic process
cellular amine metabolic process
amine metabolic process
ammonium ion metabolic process
alpha-amino acid metabolic process
cellular amino acid metabolic process
sulfur compound metabolic process
drug metabolic process
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
small molecule metabolic process