SNAP23 [The Human Chemical-Genetic Interaction Map Project]

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======= SNAP23 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SNAP23
  * **<color #00a2e8>Official Name</color>**: synaptosome associated protein 23
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8773|8773]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00161|O00161]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SNAP23&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SNAP23|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602534|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SNARE|
|SNAP-25|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histamine secretion involved in inflammatory response|
|histamine production involved in inflammatory response|
|histamine secretion by mast cell|
|histamine secretion|
|histamine transport|
|azurophil granule|
|specific granule|
|synaptic vesicle fusion to presynaptic active zone membrane|
|vesicle fusion to plasma membrane|
|synaptic vesicle priming|
|production of molecular mediator involved in inflammatory response|
|mast cell degranulation|
|mast cell activation involved in immune response|
|azole transport|
|mast cell mediated immunity|
|mast cell granule|
|mast cell activation|
|SNAP receptor activity|
|lysosome localization|
|SNARE complex|
|ammonium transport|
|syntaxin binding|
|synaptic vesicle exocytosis|
|exocytic process|
|vesicle fusion|
|hormone secretion|
|tertiary granule membrane|
|phagocytic vesicle membrane|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|
|organelle membrane fusion|
|antigen processing and presentation of exogenous peptide antigen via MHC class I|
|hormone transport|
|vesicle targeting|
|specific granule membrane|
|presynapse|
|organelle fusion|
|antigen processing and presentation of peptide antigen via MHC class I|
|neurotransmitter secretion|
|signal release from synapse|
|post-Golgi vesicle-mediated transport|
|cell-cell adherens junction|
|synaptic vesicle cycle|
|vesicle-mediated transport in synapse|
|membrane fusion|
|signal release|
|establishment of vesicle localization|
|antigen processing and presentation of exogenous peptide antigen|
|neurotransmitter transport|
|antigen processing and presentation of exogenous antigen|
|vesicle localization|
|antigen processing and presentation of peptide antigen|
|antigen processing and presentation|
|vesicle organization|
|neuron projection|
|regulation of neurotransmitter levels|
|establishment of organelle localization|
|Golgi vesicle transport|
|focal adhesion|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|trans-synaptic signaling|
|synaptic signaling|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|inflammatory response|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|regulation of hormone levels|
|organelle localization|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|cation transport|
|cellular protein-containing complex assembly|
|membrane organization|
|leukocyte activation|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|cell-cell signaling|
|secretion|
|defense response|
|ion transport|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-1.85|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|1.76|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.94|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 266/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|18/28|
|blood|12/28|
|bone|5/26|
|breast|10/33|
|central nervous system|13/56|
|cervix|0/4|
|colorectal|10/17|
|esophagus|9/13|
|fibroblast|1/1|
|gastric|10/16|
|kidney|8/21|
|liver|4/20|
|lung|21/75|
|lymphocyte|5/16|
|ovary|7/26|
|pancreas|9/24|
|peripheral nervous system|0/16|
|plasma cell|9/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|13/22|
|urinary tract|16/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 698
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SNAP23 Expression in NALM6 Cells: 6.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>