SNAP23
Gene Information
- Official Symbol: SNAP23
- Official Name: synaptosome associated protein 23
- Aliases and Previous Symbols: N/A
- Entrez ID: 8773
- UniProt: O00161
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.
Pfam Domains GO Terms
Pfam Domains
| SNARE |
| SNAP-25 |
GO Terms
| histamine secretion involved in inflammatory response |
| histamine production involved in inflammatory response |
| histamine secretion by mast cell |
| histamine secretion |
| histamine transport |
| azurophil granule |
| specific granule |
| synaptic vesicle fusion to presynaptic active zone membrane |
| vesicle fusion to plasma membrane |
| synaptic vesicle priming |
| production of molecular mediator involved in inflammatory response |
| mast cell degranulation |
| mast cell activation involved in immune response |
| azole transport |
| mast cell mediated immunity |
| mast cell granule |
| mast cell activation |
| SNAP receptor activity |
| lysosome localization |
| SNARE complex |
| ammonium transport |
| syntaxin binding |
| synaptic vesicle exocytosis |
| exocytic process |
| vesicle fusion |
| hormone secretion |
| tertiary granule membrane |
| phagocytic vesicle membrane |
| antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
| organelle membrane fusion |
| antigen processing and presentation of exogenous peptide antigen via MHC class I |
| hormone transport |
| vesicle targeting |
| specific granule membrane |
| presynapse |
| organelle fusion |
| antigen processing and presentation of peptide antigen via MHC class I |
| neurotransmitter secretion |
| signal release from synapse |
| post-Golgi vesicle-mediated transport |
| cell-cell adherens junction |
| synaptic vesicle cycle |
| vesicle-mediated transport in synapse |
| membrane fusion |
| signal release |
| establishment of vesicle localization |
| antigen processing and presentation of exogenous peptide antigen |
| neurotransmitter transport |
| antigen processing and presentation of exogenous antigen |
| vesicle localization |
| antigen processing and presentation of peptide antigen |
| antigen processing and presentation |
| vesicle organization |
| neuron projection |
| regulation of neurotransmitter levels |
| establishment of organelle localization |
| Golgi vesicle transport |
| focal adhesion |
| anterograde trans-synaptic signaling |
| chemical synaptic transmission |
| trans-synaptic signaling |
| synaptic signaling |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| inflammatory response |
| neutrophil activation |
| granulocyte activation |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| regulation of hormone levels |
| organelle localization |
| myeloid leukocyte activation |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulated exocytosis |
| leukocyte mediated immunity |
| exocytosis |
| cation transport |
| cellular protein-containing complex assembly |
| membrane organization |
| leukocyte activation |
| secretion by cell |
| export from cell |
| cell activation |
| immune effector process |
| cell-cell signaling |
| secretion |
| defense response |
| ion transport |
| protein transport |
| intracellular transport |
| peptide transport |
| protein-containing complex assembly |
| amide transport |
| establishment of protein localization |
| establishment of localization in cell |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| immune response |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Ribavirin 10 to 15μM on day4 R04 exp160 | -1.85 |
| Pifithrin-alpha 20μM R07 exp390 | 1.76 |
| Centrinone 0.5μM R07 exp343 | 1.94 |
| LLY-283 2.6μM R06 exp290 | 1.99 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 266/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 18/28 |
| blood | 12/28 |
| bone | 5/26 |
| breast | 10/33 |
| central nervous system | 13/56 |
| cervix | 0/4 |
| colorectal | 10/17 |
| esophagus | 9/13 |
| fibroblast | 1/1 |
| gastric | 10/16 |
| kidney | 8/21 |
| liver | 4/20 |
| lung | 21/75 |
| lymphocyte | 5/16 |
| ovary | 7/26 |
| pancreas | 9/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 9/15 |
| prostate | 0/1 |
| skin | 4/24 |
| soft tissue | 2/9 |
| thyroid | 0/2 |
| upper aerodigestive | 13/22 |
| urinary tract | 16/29 |
| uterus | 2/5 |
Essentiality in NALM6
- Essentiality Rank: 698
- Expression level (log2 read counts): 6.18
Expression Distribution
SNAP23 Expression in NALM6 Cells: 6.18
