SNAP91 [The Human Chemical-Genetic Interaction Map Project]

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======= SNAP91 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SNAP91
  * **<color #00a2e8>Official Name</color>**: synaptosome associated protein 91
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9892|9892]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60641|O60641]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SNAP91&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SNAP91|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607923|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ANTH|
|ENTH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|extrinsic component of presynaptic endocytic zone membrane|
|synaptic vesicle budding from presynaptic endocytic zone membrane|
|clathrin heavy chain binding|
|synaptic vesicle budding|
|1-phosphatidylinositol binding|
|regulation of clathrin-dependent endocytosis|
|clathrin coat assembly|
|clathrin-dependent endocytosis|
|synaptic vesicle transport|
|synaptic vesicle localization|
|presynaptic endocytosis|
|synaptic vesicle endocytosis|
|synaptic vesicle recycling|
|clathrin-coated pit|
|clathrin-coated vesicle|
|SNARE binding|
|presynaptic membrane|
|phosphatidylinositol-4,5-bisphosphate binding|
|vesicle budding from membrane|
|regulation of receptor-mediated endocytosis|
|synaptic vesicle cycle|
|synaptic vesicle|
|vesicle-mediated transport in synapse|
|establishment of vesicle localization|
|vesicle localization|
|regulation of endocytosis|
|receptor-mediated endocytosis|
|vesicle organization|
|establishment of organelle localization|
|protein kinase binding|
|regulation of vesicle-mediated transport|
|endocytosis|
|organelle localization|
|import into cell|
|cellular protein-containing complex assembly|
|membrane organization|
|protein transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8536
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SNAP91 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>