SNCA
Gene Information
- Official Symbol: SNCA
- Official Name: synuclein alpha
- Aliases and Previous Symbols: N/A
- Entrez ID: 6622
- UniProt: P37840
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016].
- UniProt Summary: May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
Pfam Domains GO Terms
Pfam Domains
| Synuclein |
GO Terms
| response to desipramine |
| phospholipase D inhibitor activity |
| negative regulation of catecholamine uptake involved in synaptic transmission |
| positive regulation of peroxidase activity |
| negative regulation of dopamine uptake involved in synaptic transmission |
| positive regulation of glutathione peroxidase activity |
| response to antidepressant |
| negative regulation of norepinephrine uptake |
| regulation of glutathione peroxidase activity |
| negative regulation of mitochondrial electron transport, NADH to ubiquinone |
| positive regulation of hydrogen peroxide catabolic process |
| negative regulation of mitochondrial ATP synthesis coupled electron transport |
| regulation of peroxidase activity |
| supramolecular fiber |
| regulation of norepinephrine uptake |
| regulation of thrombin-activated receptor signaling pathway |
| negative regulation of chaperone-mediated autophagy |
| negative regulation of synaptic transmission, dopaminergic |
| negative regulation of thrombin-activated receptor signaling pathway |
| negative regulation of serotonin uptake |
| catecholamine uptake involved in synaptic transmission |
| regulation of serotonin uptake |
| negative regulation of catecholamine metabolic process |
| dopamine uptake involved in synaptic transmission |
| negative regulation of cellular respiration |
| regulation of hydrogen peroxide catabolic process |
| negative regulation of dopamine metabolic process |
| regulation of mitochondrial electron transport, NADH to ubiquinone |
| response to iron(II) ion |
| negative regulation of cellular amine metabolic process |
| negative regulation of neurotransmitter uptake |
| cuprous ion binding |
| positive regulation of hydrogen peroxide metabolic process |
| regulation of mitochondrial ATP synthesis coupled electron transport |
| negative regulation of oxidative phosphorylation |
| positive regulation of cofactor metabolic process |
| regulation of dopamine uptake involved in synaptic transmission |
| regulation of chaperone-mediated autophagy |
| catecholamine uptake |
| dopamine uptake |
| regulation of catecholamine uptake involved in synaptic transmission |
| regulation of acyl-CoA biosynthetic process |
| SNARE complex assembly |
| dopamine biosynthetic process |
| dopamine transport |
| negative regulation of monooxygenase activity |
| regulation of coenzyme metabolic process |
| negative regulation of platelet-derived growth factor receptor signaling pathway |
| cellular response to epinephrine stimulus |
| negative regulation of microtubule polymerization |
| regulation of sulfur metabolic process |
| catecholamine transport |
| positive regulation of inositol phosphate biosynthetic process |
| positive regulation of receptor recycling |
| synaptic vesicle priming |
| negative regulation of histone acetylation |
| neurotransmitter reuptake |
| regulation of glutamate secretion |
| phospholipase binding |
| regulation of synaptic transmission, dopaminergic |
| regulation of inositol phosphate biosynthetic process |
| response to epinephrine |
| platelet alpha granule membrane |
| negative regulation of peptidyl-lysine acetylation |
| catecholamine biosynthetic process |
| synaptic transmission, dopaminergic |
| catechol-containing compound biosynthetic process |
| inclusion body |
| regulation of hydrogen peroxide metabolic process |
| behavioral response to cocaine |
| regulation of neurotransmitter uptake |
| regulation of dopamine metabolic process |
| regulation of catecholamine metabolic process |
| response to magnesium ion |
| negative regulation of protein acetylation |
| positive regulation of neurotransmitter secretion |
| monoamine transport |
| dynein complex binding |
| fatty acid binding |
| regulation of platelet-derived growth factor receptor signaling pathway |
| negative regulation of neurotransmitter transport |
| regulation of receptor recycling |
| regulation of synaptic vesicle recycling |
| negative regulation of oxidoreductase activity |
| ferrous iron binding |
| positive regulation of alcohol biosynthetic process |
| negative regulation of amine transport |
| nuclear outer membrane |
| negative regulation of ATP metabolic process |
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
| regulation of long-term neuronal synaptic plasticity |
| negative regulation of response to drug |
| dopamine metabolic process |
| neurotransmitter uptake |
| regulation of presynapse assembly |
| regulation of cellular respiration |
| cellular response to copper ion |
| regulation of presynapse organization |
| regulation of oxidative phosphorylation |
| microglial cell activation |
| leukocyte activation involved in inflammatory response |
| regulation of amino acid transport |
| response to iron ion |
| phenol-containing compound biosynthetic process |
| negative regulation of exocytosis |
| phosphoprotein binding |
| synaptic vesicle transport |
| regulation of cofactor metabolic process |
| negative regulation of microtubule polymerization or depolymerization |
| beta-tubulin binding |
| glial cell activation |
| positive regulation of neurotransmitter transport |
| regulation of purine nucleotide biosynthetic process |
| alpha-tubulin binding |
| regulation of dopamine secretion |
| regulation of nucleotide biosynthetic process |
| synaptic vesicle localization |
| positive regulation of release of sequestered calcium ion into cytosol |
| neuroinflammatory response |
| negative regulation of histone modification |
| Hsp70 protein binding |
| kinesin binding |
| catechol-containing compound metabolic process |
| ribosome |
| synaptic vesicle endocytosis |
| presynaptic endocytosis |
| catecholamine metabolic process |
| response to copper ion |
| tau protein binding |
| protein destabilization |
| long-term synaptic potentiation |
| negative regulation of G protein-coupled receptor signaling pathway |
| terminal bouton |
| macrophage activation |
| regulation of microtubule polymerization |
| regulation of macrophage activation |
| synaptic vesicle recycling |
| ammonium transport |
| regulation of neuronal synaptic plasticity |
| positive regulation of oxidoreductase activity |
| regulation of monooxygenase activity |
| positive regulation of calcium ion transport into cytosol |
| response to cocaine |
| regulation of histone acetylation |
| copper ion binding |
| positive regulation of cellular carbohydrate metabolic process |
| regulation of organic acid transport |
| rough endoplasmic reticulum |
| negative regulation of chromatin organization |
| negative regulation of synaptic transmission |
| receptor internalization |
| regulation of peptidyl-lysine acetylation |
| regulation of catecholamine secretion |
| excitatory postsynaptic potential |
| synaptic vesicle exocytosis |
| SNARE binding |
| negative regulation of protein polymerization |
| chemical synaptic transmission, postsynaptic |
| exocytic process |
| synaptic vesicle membrane |
| positive regulation of calcium ion transmembrane transport |
| regulation of protein acetylation |
| vesicle fusion |
| regulation of phospholipase activity |
| regulation of alcohol biosynthetic process |
| organelle membrane fusion |
| mitochondrial intermembrane space |
| adult locomotory behavior |
| response to anesthetic |
| regulation of release of sequestered calcium ion into cytosol |
| positive regulation of carbohydrate metabolic process |
| negative regulation of transporter activity |
| regulation of microtubule polymerization or depolymerization |
| regulation of cellular amine metabolic process |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| negative regulation of autophagy |
| postsynapse |
| phenol-containing compound metabolic process |
| regulation of reactive oxygen species biosynthetic process |
| regulation of fatty acid metabolic process |
| activation of cysteine-type endopeptidase activity involved in apoptotic process |
| positive regulation of exocytosis |
| negative regulation of cysteine-type endopeptidase activity |
| mitochondrial ATP synthesis coupled electron transport |
| positive regulation of neuron death |
| ATP synthesis coupled electron transport |
| regulation of amine transport |
| regulation of carbohydrate biosynthetic process |
| positive regulation of reactive oxygen species metabolic process |
| regulation of anion transport |
| regulation of oxidoreductase activity |
| organelle fusion |
| regulation of lipase activity |
| regulation of response to drug |
| regulation of calcium ion transport into cytosol |
| regulation of postsynaptic membrane potential |
| positive regulation of endocytosis |
| neutral lipid metabolic process |
| signal release from synapse |
| cellular response to monoamine stimulus |
| cellular response to catecholamine stimulus |
| neurotransmitter secretion |
| receptor metabolic process |
| regulation of synapse assembly |
| phospholipid binding |
| positive regulation of peptidyl-serine phosphorylation |
| regulation of neurotransmitter secretion |
| response to monoamine |
| response to catecholamine |
| protein N-terminus binding |
| cellular response to fibroblast growth factor stimulus |
| respiratory electron transport chain |
| regulation of synaptic vesicle cycle |
| response to alkaloid |
| response to fibroblast growth factor |
| regulation of purine nucleotide metabolic process |
| oxidative phosphorylation |
| synaptic vesicle cycle |
| regulation of nucleotide metabolic process |
| oxidoreductase activity |
| regulation of ATP metabolic process |
| positive regulation of calcium ion transport |
| regulation of sequestering of calcium ion |
| mitochondrial membrane organization |
| growth cone |
| vesicle-mediated transport in synapse |
| negative regulation of protein complex assembly |
| histone binding |
| membrane fusion |
| negative regulation of supramolecular fiber organization |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| negative regulation of protein catabolic process |
| negative regulation of chromosome organization |
| cell cortex |
| regulation of peptidyl-serine phosphorylation |
| organic hydroxy compound transport |
| positive regulation of small molecule metabolic process |
| negative regulation of cytoskeleton organization |
| regulation of cellular carbohydrate metabolic process |
| positive regulation of inflammatory response |
| positive regulation of cation transmembrane transport |
| regulation of neurotransmitter transport |
| regulation of G protein-coupled receptor signaling pathway |
| negative regulation of neuron apoptotic process |
| adult behavior |
| regulation of histone modification |
| regulation of calcium ion transmembrane transport |
| negative regulation of ion transport |
| drug transport |
| protein tetramerization |
| positive regulation of synaptic transmission |
| positive regulation of cysteine-type endopeptidase activity |
| positive regulation of ion transmembrane transport |
| regulation of generation of precursor metabolites and energy |
| mitochondrial outer membrane |
| cellular respiration |
| signal release |
| regulation of cellular ketone metabolic process |
| positive regulation of endopeptidase activity |
| establishment of vesicle localization |
| regulation of reactive oxygen species metabolic process |
| neurotransmitter transport |
| response to interferon-gamma |
| electron transport chain |
| vesicle localization |
| response to ammonium ion |
| organic hydroxy compound biosynthetic process |
| regulation of microtubule cytoskeleton organization |
| regulation of chromatin organization |
| regulation of synaptic plasticity |
| cellular response to metal ion |
| positive regulation of peptidase activity |
| ammonium ion metabolic process |
| locomotory behavior |
| response to interleukin-1 |
| positive regulation of transmembrane transport |
| negative regulation of secretion by cell |
| ATP metabolic process |
| regulation of carbohydrate metabolic process |
| regulation of endocytosis |
| regulation of neuron apoptotic process |
| negative regulation of neuron death |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| magnesium ion binding |
| actin cytoskeleton |
| regulation of synapse organization |
| transcription regulatory region DNA binding |
| cellular response to inorganic substance |
| regulation of microtubule-based process |
| regulation of exocytosis |
| regulation of protein polymerization |
| regulation of synapse structure or activity |
| negative regulation of secretion |
| energy derivation by oxidation of organic compounds |
| receptor-mediated endocytosis |
| microtubule binding |
| cellular response to oxidative stress |
| regulation of cysteine-type endopeptidase activity |
| negative regulation of endopeptidase activity |
| protein domain specific binding |
| regulation of calcium ion transport |
| lysosome |
| negative regulation of cellular catabolic process |
| negative regulation of peptidase activity |
| regulation of transmembrane transporter activity |
| actin binding |
| synapse organization |
| positive regulation of ion transport |
| regulation of transporter activity |
| aging |
| positive regulation of cytosolic calcium ion concentration |
| regulation of protein stability |
| axon |
| vesicle organization |
| response to xenobiotic stimulus |
| negative regulation of catabolic process |
| regulation of neuron death |
| response to lipopolysaccharide |
| fatty acid metabolic process |
| response to molecule of bacterial origin |
| regulation of cytosolic calcium ion concentration |
| regulation of autophagy |
| regulation of cation transmembrane transport |
| regulation of inflammatory response |
| positive regulation of protein serine/threonine kinase activity |
| regulation of chromosome organization |
| regulation of supramolecular fiber organization |
| regulation of neurotransmitter levels |
| negative regulation of proteolysis |
| positive regulation of proteolysis |
| establishment of organelle localization |
| positive regulation of cellular catabolic process |
| mitochondrial matrix |
| response to metal ion |
| neuronal cell body |
| negative regulation of organelle organization |
| phospholipid metabolic process |
| regulation of protein catabolic process |
| regulation of metal ion transport |
| response to oxidative stress |
| mitochondrial inner membrane |
| regulation of lipid metabolic process |
| regulation of cellular amide metabolic process |
| positive regulation of secretion by cell |
| negative regulation of protein phosphorylation |
| regulation of endopeptidase activity |
| anterograde trans-synaptic signaling |
| chemical synaptic transmission |
| generation of precursor metabolites and energy |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| regulation of small molecule metabolic process |
| regulation of membrane potential |
| positive regulation of catabolic process |
| positive regulation of secretion |
| cellular calcium ion homeostasis |
| trans-synaptic signaling |
| modulation of chemical synaptic transmission |
| mitochondrion organization |
| regulation of trans-synaptic signaling |
| negative regulation of phosphorylation |
| regulation of peptidase activity |
| calcium ion homeostasis |
| regulation of protein complex assembly |
| negative regulation of hydrolase activity |
| organic hydroxy compound metabolic process |
| supramolecular fiber organization |
| synaptic signaling |
| cellular divalent inorganic cation homeostasis |
| positive regulation of defense response |
| regulation of ion transmembrane transport |
| negative regulation of transport |
| divalent inorganic cation homeostasis |
| inflammatory response |
| cellular response to growth factor stimulus |
| drug metabolic process |
| regulation of protein serine/threonine kinase activity |
| protein complex oligomerization |
| monocarboxylic acid metabolic process |
| response to growth factor |
| response to inorganic substance |
| positive regulation of protein kinase activity |
| regulation of cytoskeleton organization |
| cellular response to organic cyclic compound |
| cell junction |
| regulation of vesicle-mediated transport |
| endocytosis |
| cellular metal ion homeostasis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| regulation of transmembrane transport |
| behavior |
| positive regulation of kinase activity |
| organelle localization |
| myeloid leukocyte activation |
| negative regulation of protein modification process |
| cellular response to organonitrogen compound |
| regulation of leukocyte activation |
| positive regulation of response to external stimulus |
| metal ion homeostasis |
| cellular cation homeostasis |
| regulation of cell activation |
| positive regulation of apoptotic process |
| cellular ion homeostasis |
| positive regulation of programmed cell death |
| positive regulation of transferase activity |
| cellular response to nitrogen compound |
| import into cell |
| response to bacterium |
| positive regulation of cell death |
| perinuclear region of cytoplasm |
| regulation of ion transport |
| regulated exocytosis |
| negative regulation of cellular component organization |
| cation homeostasis |
| inorganic ion homeostasis |
| calcium ion binding |
| regulation of proteolysis |
| cellular chemical homeostasis |
| regulation of secretion by cell |
| regulation of defense response |
| innate immune response |
| positive regulation of hydrolase activity |
| ion homeostasis |
| negative regulation of catalytic activity |
| exocytosis |
| regulation of protein kinase activity |
| regulation of secretion |
| cation transport |
| regulation of cellular catabolic process |
| zinc ion binding |
| cellular protein-containing complex assembly |
| response to lipid |
| membrane organization |
| negative regulation of transcription by RNA polymerase II |
| regulation of kinase activity |
| organophosphate metabolic process |
| negative regulation of apoptotic process |
| cellular homeostasis |
| negative regulation of programmed cell death |
| carboxylic acid metabolic process |
| regulation of cellular localization |
| response to organic cyclic compound |
| apoptotic process |
| regulation of nervous system development |
| leukocyte activation |
| defense response to other organism |
| cellular lipid metabolic process |
| regulation of cellular component biogenesis |
| oxidation-reduction process |
| regulation of transferase activity |
| regulation of locomotion |
| Golgi apparatus |
| positive regulation of transport |
| negative regulation of cell death |
| regulation of catabolic process |
| response to organonitrogen compound |
| oxoacid metabolic process |
| secretion by cell |
| positive regulation of protein phosphorylation |
| response to drug |
| organic acid metabolic process |
| negative regulation of cellular protein metabolic process |
| export from cell |
| programmed cell death |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| identical protein binding |
| cell activation |
| response to nitrogen compound |
| cell death |
| regulation of response to external stimulus |
| response to cytokine |
| negative regulation of protein metabolic process |
| chemical homeostasis |
| cell-cell signaling |
| secretion |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| aromatic compound biosynthetic process |
| negative regulation of transcription, DNA-templated |
| positive regulation of cellular component organization |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| mitochondrion |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| phosphorylation |
| regulation of organelle organization |
| response to other organism |
| organic cyclic compound biosynthetic process |
| response to external biotic stimulus |
| response to biotic stimulus |
| negative regulation of RNA metabolic process |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| ion transport |
| nervous system process |
| negative regulation of cellular macromolecule biosynthetic process |
| organonitrogen compound biosynthetic process |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| homeostatic process |
| regulation of immune system process |
| regulation of cell death |
| cellular response to stress |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| small molecule metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| establishment of localization in cell |
| regulation of protein modification process |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| regulation of transport |
| immune response |
| extracellular region |
| vesicle-mediated transport |
| system process |
| positive regulation of cellular biosynthetic process |
| membrane |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Bisphenol S 100μM R08 exp458 | 1.7 |
| Arsenic trioxide 60μM R08 exp449 | 1.9 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7718
- Expression level (log2 read counts): -1.17
Expression Distribution
SNCA Expression in NALM6 Cells: -1.17
