SNF8 [The Human Chemical-Genetic Interaction Map Project]

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======= SNF8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SNF8
  * **<color #00a2e8>Official Name</color>**: SNF8 subunit of ESCRT-II
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11267|11267]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96H20|Q96H20]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SNF8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SNF8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610904|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:17714434, ECO:0000269|PubMed:17959629, ECO:0000269|PubMed:18031739, ECO:0000269|PubMed:22660413}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EAP30|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of multivesicular body size involved in endosome transport|
|regulation of multivesicular body size|
|ESCRT II complex|
|regulation of viral budding via host ESCRT complex|
|protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|
|regulation of endosome size|
|late endosome to vacuole transport via multivesicular body sorting pathway|
|channel regulator activity|
|regulation of protein complex stability|
|positive regulation of exosomal secretion|
|late endosome to vacuole transport|
|regulation of exosomal secretion|
|early endosome to late endosome transport|
|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|
|vesicle-mediated transport between endosomal compartments|
|endosome transport via multivesicular body sorting pathway|
|multivesicular body assembly|
|multivesicular body organization|
|multivesicular body sorting pathway|
|endocytic recycling|
|establishment of protein localization to vacuole|
|protein localization to vacuole|
|endosome organization|
|positive regulation of exocytosis|
|protein N-terminus binding|
|recycling endosome|
|late endosome membrane|
|vacuolar transport|
|regulation of viral life cycle|
|cytosolic transport|
|macroautophagy|
|protein C-terminus binding|
|regulation of viral process|
|transcription factor complex|
|endosome membrane|
|positive regulation of protein catabolic process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of exocytosis|
|endosomal transport|
|process utilizing autophagic mechanism|
|autophagy|
|vesicle organization|
|transcription factor binding|
|regulation of MAP kinase activity|
|regulation of cellular component size|
|regulation of protein catabolic process|
|positive regulation of secretion by cell|
|endomembrane system organization|
|establishment of protein localization to organelle|
|positive regulation of catabolic process|
|positive regulation of secretion|
|regulation of anatomical structure size|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cellular component biogenesis|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|regulation of vesicle-mediated transport|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|perinuclear region of cytoplasm|
|protein localization to organelle|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|organelle assembly|
|regulation of multi-organism process|
|regulation of protein kinase activity|
|regulation of secretion|
|regulation of kinase activity|
|protein homodimerization activity|
|cellular macromolecule catabolic process|
|regulation of cellular component biogenesis|
|regulation of transferase activity|
|positive regulation of transport|
|intracellular protein transport|
|regulation of catabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|proteolysis|
|regulation of protein phosphorylation|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of protein modification process|
|regulation of transport|
|vesicle-mediated transport|
|positive regulation of gene expression|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-3.09|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-2.68|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|-2.67|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-2.42|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-2.34|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-2.34|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-2.26|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|-2.24|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-2.21|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-2.21|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-2.2|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-2.19|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-2.19|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-2.18|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-2.18|
|[[:results:exp114|A-196 10μM R03 exp114]]|-2.13|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-2.13|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-2.12|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-2.09|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-2.08|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.08|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-2.08|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-2.06|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-2.05|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-2.02|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-2.02|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-2.01|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-1.96|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.95|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.93|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|-1.91|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-1.88|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.87|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-1.86|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.86|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-1.86|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-1.85|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-1.84|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-1.84|
|[[:results:exp285|GW501516 25μM R06 exp285]]|-1.82|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-1.82|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-1.79|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-1.79|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-1.79|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|-1.78|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|-1.78|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.77|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-1.75|
|[[:results:exp132|Metformin 40μM R03 exp132]]|-1.74|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-1.74|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-1.73|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-1.73|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-1.73|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-1.73|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|-1.72|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-1.72|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|-1.72|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.72|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.71|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.78|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.8|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gnb1l|GNB1L]]|0.507|
|[[:human genes:e:eprs|EPRS]]|0.487|
|[[:human genes:a:alg13|ALG13]]|0.475|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.468|
|[[:human genes:c:cdipt|CDIPT]]|0.466|
|[[:human genes:g:gmppb|GMPPB]]|0.458|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.454|
|[[:human genes:t:thg1l|THG1L]]|0.453|
|[[:human genes:t:telo2|TELO2]]|0.442|
|[[:human genes:r:rnmt|RNMT]]|0.439|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.439|
|[[:human genes:s:snapc5|SNAPC5]]|0.437|
|[[:human genes:m:mars|MARS]]|0.433|
|[[:human genes:g:gemin6|GEMIN6]]|0.432|
|[[:human genes:r:rpp21|RPP21]]|0.431|
|[[:human genes:d:dhps|DHPS]]|0.428|
|[[:human genes:r:rtcb|RTCB]]|0.423|
|[[:human genes:s:srp14|SRP14]]|0.423|
|[[:human genes:d:ddx20|DDX20]]|0.423|
|[[:human genes:a:alg1|ALG1]]|0.422|
|[[:human genes:d:dpagt1|DPAGT1]]|0.419|
|[[:human genes:t:tti2|TTI2]]|0.418|
|[[:human genes:u:uap1|UAP1]]|0.412|
|[[:human genes:p:pmm2|PMM2]]|0.411|
|[[:human genes:g:gemin8|GEMIN8]]|0.407|
|[[:human genes:v:vezt|VEZT]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 337/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|13/28|
|blood|14/28|
|bone|13/26|
|breast|20/33|
|central nervous system|25/56|
|cervix|3/4|
|colorectal|6/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|10/16|
|kidney|5/21|
|liver|12/20|
|lung|27/75|
|lymphocyte|6/16|
|ovary|15/26|
|pancreas|11/24|
|peripheral nervous system|2/16|
|plasma cell|8/15|
|prostate|1/1|
|skin|11/24|
|soft tissue|7/9|
|thyroid|1/2|
|upper aerodigestive|9/22|
|urinary tract|15/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1552
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SNF8 Expression in NALM6 Cells: 5.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>