SNF8

Gene Information

Official Symbol: SNF8
Official Name: SNF8 subunit of ESCRT-II
Aliases and Previous Symbols: N/A
Entrez ID: 11267
UniProt: Q96H20
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:17714434, ECO:0000269|PubMed:17959629, ECO:0000269|PubMed:18031739, ECO:0000269|PubMed:22660413}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Palbociclib 1μM R07 exp382	-3.09
NN-Diethyl-meta-toluamide 100μM R05 exp237	-2.68
Pyrazinamide 100μM R08 exp516	-2.67
Talazoparib 0.006μM R06 exp299	-2.42
GSK591 2.6μM R03 exp128	-2.34
Rifampicin 30μM R08 exp430	-2.34
HMS-I1 1μM R01 exp46	-2.26
Glyphosate 1000μM R06 exp283	-2.24
Cabazitaxel 0.001μM R05 exp223	-2.21
Dynasore 7μM R08 exp436	-2.21
BI-D1870 2μM R04 exp162	-2.2
Resveratrol 16μM R03 exp147	-2.19
UMK57 0.6μM R03 exp107	-2.19
Dihydrosphingosine 8μM R08 exp476	-2.18
Trichostatin-A 0.06μM R07 exp415	-2.18
A-196 10μM R03 exp114	-2.13
Temozolomide 200μM R04 exp189	-2.13
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-2.12
A-395N 10μM R05 exp219	-2.09
IU1-C 25μM R04 exp183	-2.08
Radicicol 0.16μM R05 exp242	-2.08
Vinorelbine 0.001μM R05 exp249	-2.08
Caffeine 2600μM R08 exp463	-2.06
BI-2536 0.001μM R01 exp41	-2.05
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-2.02
UM0131023 0.05μM R05 exp248	-2.02
Rapamycin 2μM plus FK-506 5μM R07 exp308	-2.01
Q15 1 to 2μM on day4 R04 exp164	-1.96
I-BRD9 4μM R07 exp365	-1.95
TRAIL 5ng/ml R00 exp35	-1.93
Thalidomide 20μM R07 exp406	-1.91
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-1.88
BI-6727 0.0125μM R03 exp97	-1.87
Calcium Ionophore 0.4μM R07 exp342	-1.86
Etoposide 0.3μM R05 exp199	-1.86
Mubritinib 0.2μM R02 exp65	-1.86
KU-0063794 3.8μM R02 exp71	-1.85
Dimethyloxaloylglycine 100μM R05 exp229	-1.84
VHL-ligand-1 20μM R07 exp421	-1.84
GW501516 25μM R06 exp285	-1.82
HMS-I2 1μM R06 exp286	-1.82
2-Methoxyestradiol 0.55μM R07 exp310	-1.79
Betulinic acid 10 to 15μM on day4 R05 exp222	-1.79
Salubrinal 20μM R07 exp399	-1.79
SGC0649 7μM R03 exp150	-1.78
TGF-beta1 44ng/ml R08 exp528	-1.78
UM131593 0.2μM R03 exp106	-1.77
Hydroxychloroquine 30μM R08 exp490	-1.75
Metformin 40μM R03 exp132	-1.74
Zebularine 20μM R07 exp423	-1.74
Cyclosporin-A 3μM R07 exp348	-1.73
JQ1 0.01μM R03 exp130	-1.73
NFN1 0.4μM R03 exp99	-1.73
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	-1.73
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	-1.72
Dexamethasone 0.006μM R07 exp351	-1.72
Ibrutinib 1μM R07 exp372	-1.72
Latrunculin-B 10μM R07 exp374	-1.72
Doxycycline 10μM R00 exp18	-1.71
Hinokiflavone 12μM R08 exp487	1.78
SNS-032 15μM R08 exp443	1.8
THZ1 0.06μM R08 exp531	1.95

Gene	Correlation
GNB1L	0.507
EPRS	0.487
ALG13	0.475
GTF3C3	0.468
CDIPT	0.466
GMPPB	0.458
GTF3C2	0.454
THG1L	0.453
TELO2	0.442
RNMT	0.439
GTF3C6	0.439
SNAPC5	0.437
MARS	0.433
GEMIN6	0.432
RPP21	0.431
DHPS	0.428
RTCB	0.423
SRP14	0.423
DDX20	0.423
ALG1	0.422
DPAGT1	0.419
TTI2	0.418
UAP1	0.412
PMM2	0.411
GEMIN8	0.407
VEZT	0.401

Global Fraction of Cell Lines Where Essential: 337/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	13/28
blood	14/28
bone	13/26
breast	20/33
central nervous system	25/56
cervix	3/4
colorectal	6/17
esophagus	4/13
fibroblast	0/1
gastric	10/16
kidney	5/21
liver	12/20
lung	27/75
lymphocyte	6/16
ovary	15/26
pancreas	11/24
peripheral nervous system	2/16
plasma cell	8/15
prostate	1/1
skin	11/24
soft tissue	7/9
thyroid	1/2
upper aerodigestive	9/22
urinary tract	15/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 1552
Expression level (log2 read counts): 5.99

Expression Distribution

regulation of multivesicular body size involved in endosome transport
regulation of multivesicular body size
ESCRT II complex
regulation of viral budding via host ESCRT complex
protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
regulation of endosome size
late endosome to vacuole transport via multivesicular body sorting pathway
channel regulator activity
regulation of protein complex stability
positive regulation of exosomal secretion
late endosome to vacuole transport
regulation of exosomal secretion
early endosome to late endosome transport
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
vesicle-mediated transport between endosomal compartments
endosome transport via multivesicular body sorting pathway
multivesicular body assembly
multivesicular body organization
multivesicular body sorting pathway
endocytic recycling
establishment of protein localization to vacuole
protein localization to vacuole
endosome organization
positive regulation of exocytosis
protein N-terminus binding
recycling endosome
late endosome membrane
vacuolar transport
regulation of viral life cycle
cytosolic transport
macroautophagy
protein C-terminus binding
regulation of viral process
transcription factor complex
endosome membrane
positive regulation of protein catabolic process
regulation of symbiosis, encompassing mutualism through parasitism
regulation of exocytosis
endosomal transport
process utilizing autophagic mechanism