SNN [The Human Chemical-Genetic Interaction Map Project]

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======= SNN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SNN
  * **<color #00a2e8>Official Name</color>**: stannin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8303|8303]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75324|O75324]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SNN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SNN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603032|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the toxic effects of organotins (PubMed:15269288). Plays a role in endosomal maturation (PubMed:27015288). {ECO:0000269|PubMed:15269288, ECO:0000269|PubMed:27015288}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SNN linker|
|SNN cytoplasm|
|SNN transmemb|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial outer membrane|
|response to toxic substance|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.48|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.77|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|1.77|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.07|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|2.12|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|2.19|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|2.37|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.54|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|3|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|3.27|
|[[:results:exp210|LB-100 2μM R05 exp210]]|3.39|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|5.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14188
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SNN Expression in NALM6 Cells: 5.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>