SNN

Entrez Summary: N/A
UniProt Summary: Plays a role in the toxic effects of organotins (PubMed:15269288). Plays a role in endosomal maturation (PubMed:27015288). {ECO:0000269|PubMed:15269288, ECO:0000269|PubMed:27015288}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vemurafenib 6.6μM R08 exp434	-2.48
Colchicine 0.009μM R05 exp215	1.77
Etoposide 0.1μM R05 exp198	1.77
ML-792 0.2μM R08 exp505	2.07
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	2.12
Docetaxel 0.002μM R01 exp45	2.19
LB-100 4.1μM R02 exp72	2.37
THZ531 0.225μM R08 exp444	2.54
Pyridostatin 4μM R05 exp240	3
Actinomycin-D 0.001μM R00 exp3	3.27
LB-100 2μM R05 exp210	3.39
Vincristine 0.0005μM R04 exp190	5.05

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

mitochondrial outer membrane
response to toxic substance